PhD \"Micro-endoscopic probe for stimulated Raman histology\" (M/F)

CNRS; France; Sur place; EUR 19 000 - 23 000; Plein temps

Résumé du poste

CNRS, through the PhLAM laboratory in Lille, invites applications for a PhD project focused on developing a miniature optical probe for stimulated Raman histology to enable real-time tissue imaging.

The PhD will involve cutting-edge optics, hollow-core fibres, and instrument control, with collaboration between Lille, Aix-Marseille University, and Lightcore Technologies. Candidates should show independence and strong practical problem-solving skills.

Qualifications

• Strong interest in experimental optics.
• Experience with optical experimentation and basic electronics.
• Ability to work independently.
• Good problem-solving skills.

Responsabilités

• Develop miniature optical probe design for stimulated Raman histology.
• Collaborate with researchers at Lille and partners.
• Contribute to data collection and analysis.
• Assist in instrument development and testing.

Connaissances

Instrument control

Electronics

Optical design

Image processing

Independence

Initiative

Experimental optics

Formation

Master's degree in Physics or related field

Outils

Zemax

Description du poste

Organisation/Company CNRS Department Physique des lasers, atomes et molécules Research Field Physics Researcher Profile First Stage Researcher (R1) Application Deadline 16 Nov 2026 - 23:59 (UTC) Country France Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Jan 2027 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Endoscopic techniques are essential for the diagnosis, staging and treatment of epithelial cancers. For many cancers, they are often the only way to access the tumour site directly. However, precancerous tissues sometimes exhibit subtle changes that cannot be detected visually. Endoscopic cancer detection has two main limitations: (1) the limited sensitivity of commonly used fluorescent markers and (2) the need for biopsies and histological analyses, which delay surgery and clinical decision-making.

This PhD project aims to develop a miniature optical probe for stimulated Raman histology able to provide real-time tissue images that closely match conventional histology (H&E staining). This approach aims to enable earlier and less invasive detection of gastroenterological cancers, while also exploring its potential for detecting urological cancers and assessing tumour margins during surgery.

We propose an innovative approach combining stimulated Raman scattering (SRS) microscopy, state-of-the-art hollow-core fibres, and advanced technologies for assembling miniature fibre-optic micro-endoscopic probes. The goal is to develop an SRS endoscopic probe capable of performing stimulated Raman histology in real time. The technology will be developed for applications in gastroenterological and urological cancers, with validation on relevant biological tissues in collaboration with clinical partners.

The PhD will be carried out at the PhLAM laboratory at the University of Lille, under the supervision of Alexandre Kudlinski, in close collaboration with Hervé Rigneault (Institut Fresnel, Aix-Marseille University) and Lightcore Technologies, a company based in Lille and Marseille.

This PhD project is strongly experimental in nature, focusing on optics, optical fibres, and ultrashort-pulse lasers. Skills in instrument control, electronics, optical design (particularly using software such as Zemax) and image processing would be an advantage. The candidate should have a strong interest in experimental optics, and demonstrate independence, initiative, and good practical problem-solving skills.

Micro-endoscopic probe for stimulated Raman histology