PhD in Computational Systems Biology for AMD Digital Twin

CNRS - IPBS and CBI-Toulouse; France; On-site; EUR 26,000 - 31,000; Full time

Benefits offered by this job

PhD stipend

Research funding

Job summary

CNRS - IPBS and CBI-Toulouse invites a highly motivated PhD student to join the MSCA PANDORA doctoral network at the Centre for Integrative Biology in Toulouse, France. You will create large-scale molecular interaction maps of retinal mechanisms linked to AMD, convert them into Boolean models, and integrate ABM to build a digital twin of the retina under AMD conditions.

Strong background in computational biology, bioinformatics or quantitative biology and excellent English are required;

Qualifications

• Master's degree in bioinformatics, computational or systems biology, biology with quantitative focus, computer science, applied mathematics or closely related field.
• Programming experience (Python, R or similar) and knowledge of network biology, modelling and omics data analysis.
• Excellent command of English, both spoken and written.
• Strong motivation for pathological mechanisms and translational biomedical research.
• Ability to work independently and in an interdisciplinary team.

Responsibilities

• Develop large-scale molecular interaction maps of retinal mechanisms linked to AMD and the complement system.
• Convert maps into executable Boolean models using map-to-model framework.
• Integrate models into an ABM to create a digital twin of the retina affected by AMD.
• Compare in silico predictions with experimental data from project partners.
• Identify potential therapeutic targets for AMD and support validation work.

Skills

Bioinformatics

Systems biology

Python

R language

Omics data analysis

English proficiency

Team collaboration

Boolean modelling

Agent-based modelling

Education

Master's in bioinformatics

Tools

Python

R

Job description

CNRS - IPBS and CBI-Toulouse invites a highly motivated PhD student to join the MSCA PANDORA doctoral network at the Centre for Integrative Biology in Toulouse, France. You will create large-scale molecular interaction maps of retinal mechanisms linked to AMD, convert them into Boolean models, and integrate ABM to build a digital twin of the retina under AMD conditions.

Strong background in computational biology, bioinformatics or quantitative biology and excellent English are required;