PhD in AMD Immunology: Complement & Microglia Dynamics

Institut de la vision; Paris; On-site; EUR 27,000 - 36,000; Full time

Job summary

Institut de la Vision in Paris seeks a PhD candidate to investigate how complement dysregulation drives mononuclear phagocyte accumulation in AMD within the MSCA PANDORA network.

The project uses human retina tissue, iPSC-derived cells, immunohistochemistry, flow cytometry, and omics analyses to map pathways and test inhibitors. Excellent English required; Master's degree in life sciences preferred.

Qualifications

• Master's degree in life sciences, biology, immunology, neurobiology or biomedical sciences.
• Excellent written and oral English proficiency.
• Strong motivation for research on retinal degeneration and neuroinflammation.
• Ability to work both in a team and independently.

Responsibilities

• Map complement cascade components in human retina using post-mortem tissue.
• Localise components relative to subretinal MPs, RPE, photoreceptors and drusen.
• Study chr1-risk haplotype effects using control and iPSC-derived cells.
• Apply single-cell and bulk RNA sequencing and proteomics to assess dysregulation.
• Test complement inhibitors (anti-C5, anti-C3) for restoring balance.

Skills

Cellular biology

Immunology

English proficiency

Teamwork

Research motivation

Education

Master's degree or equivalent

Tools

Immunohistochemistry

Flow cytometry

Job description

Institut de la Vision in Paris seeks a PhD candidate to investigate how complement dysregulation drives mononuclear phagocyte accumulation in AMD within the MSCA PANDORA network.

The project uses human retina tissue, iPSC-derived cells, immunohistochemistry, flow cytometry, and omics analyses to map pathways and test inhibitors. Excellent English required; Master's degree in life sciences preferred.