Nanoparticles formulation and analytical R&D

Doxanano; Pessac; Sur place; EUR 20 000 - 40 000; Plein temps

Résumé du poste

Une start-up innovante recherche un Ingénieur R&D spécialisé dans la formulation de nanoparticules et l'analyse pour contribuer à des projets révolutionnaires en oncologie. Ce rôle passionnant implique le développement de formulations de nanoparticules, l'optimisation des profils de libération et la collaboration avec des équipes interdisciplinaires. En rejoignant cette équipe dynamique, vous aurez l'opportunité de travailler sur des technologies de pointe visant à améliorer les traitements pour les patients atteints de tumeurs solides. Si vous êtes motivé par l'innovation et désireux de faire une différence, cette position est faite pour vous.

Prestations

Contribuer à des projets révolutionnaires

Expérience pratique dans un environnement dynamique

Culture de travail collaborative et supportive

Qualifications

• Minimum 5 ans d'expérience en environnement Pharma ou Biotech, de préférence en oncologie.
• Familiarité avec les exigences réglementaires pour les produits pharmaceutiques (FDA, EMA).

Responsabilités

• Développer et optimiser des formulations de nanoparticules pour la délivrance de médicaments cytotoxiques.
• Collaborer avec des équipes interfonctionnelles pour passer du laboratoire à la production.

Connaissances

Formulation de nanoparticules

Techniques d'encapsulation de nanoparticules

Techniques analytiques (DLS, HPLC)

Connaissance des processus de fabrication pharmaceutique

Compétences analytiques et de résolution de problèmes

Formation

Master 2 en Sciences Pharmaceutiques

Outils

Microscopie

Spectrométrie de masse

Description du poste

Pessac (33), France

Long term contract

Desired start date: May 1st, 2025

Qualification

• Minimum master 2 in Pharmaceutical Sciences, Formulation/Colloidal Science, Nanotechnology, or a related field.
• Minimum 5 years of experience in Pharma or Biotech environment (companies, start-up, CDMOs, …), preferably in Oncology.

About Doxanano

Doxanano is a start-up created in 2023 by Isabel Marey-Semper and co-founded by Pr Sébastien Lecommandoux, director of the Laboratoire de Chimie des Polymères Organiques in Bordeaux, and Dr Leslie Dubrana.

Doxanano is committed to pushing the limits of conventional chemotherapy for patients with solid tumors. Our goal is to significantly increase the quantity of chemotherapeutic agents into the tumor whilst dramatically limiting adverse effects on healthy organs. We specialize in harnessing the unique properties of our DXN polymersomes drug delivery platform in combination with the precision of radiotherapy.

Your mission

Your mission focuses on developing the formulation, drug loading and analytical characterization of breakthrough polymer-based nanovesicles, with the aim of scaling them up to GLP and GMP grades in the field of oncology.

Your key Responsibilities

You will join the R&D team and take part in Doxanano’s technological development. As such, we are seeking an Engineer with expertise in the development of nanoparticles, drug loading and controlled release with the following responsibilities:

• Develop and optimize nanoparticle-based formulations for cytotoxic drug delivery
• Perform characterization including particle size, drug loading, and release profile optimization
• Develop flow-microfluidic formulation
• Develop specific analytical methods for each encapsulated drug
• Develop specific analytical methods for drug release profile evaluation
• Ensure formulations meet GLP and GMP standards

And later on,

• Contribute to develop AI-based nanoparticles models with the AI team
• Collaborate with cross-functional teams for scaling from lab to production
• Document work in line with GMP/GLP requirements

Your profile

• Strong experience in nanoparticles formulation, nanoparticle encapsulation techniques preferably with cytotoxic drugs or other active pharmaceutical ingredients (APIs);
• Strong knowledge of pharmaceutical manufacturing processes in particular microfluidic assisted formulation;
• Experience in analytical techniques for the characterization of drug loaded nanoparticles (DLS, HPLC, microscopy, mass spectroscopy, …) and formulation quality control;
• Familiarity with regulatory requirements for pharmaceuticals (FDA, EMA) and experience working under GMP or GLP conditions is a plus;
• Strong analytical and problem-solving skills;
• Knowledge of Data would be a plus;
• Willing and happy to perform day-to-day experiments;
• Ability to work independently as well as in a team;

And last but not least, you are results-oriented and ready to take initiatives with a sense of urgency!

What We Offer

• The opportunity to contribute to breakthrough projects in a start-up environment
• A hands-on experience in a dynamic research and development environment
• The integration into an inter-disciplinary project from research to clinics
• A collaborative and supportive workplace culture

Application Process

Send your resume to [e-mail] with the subject line » Nanoparticles formulation and analytical R&D Engineer – Job Offer «.

We look forward to your application and the possibility of you joining our team to contribute to the exciting advancements in polymer science to save lives!