Job offer

UMR 261; Marseille; Sur place; EUR 40 000 - 60 000; Plein temps

Résumé du poste

An established research organization is seeking a dedicated researcher for a project focused on the development of antimalarial compounds. This role involves synthesizing and optimizing compounds that have shown promising activity against malaria. The successful candidate will work closely with expert teams in a collaborative environment, engaging in cutting-edge research at the intersection of chemistry and biology. With a commitment to advancing therapeutic solutions, this position offers a unique opportunity to contribute to significant scientific advancements while being part of a dynamic research community.

Qualifications

• M2 in Organic Chemistry required with a strong academic record.
• Experience in biology is necessary for thesis completion.

Responsabilités

• Conduct research on antimalarial compounds using combinatorial chemistry.
• Evaluate biological activity and optimize physicochemical properties.

Connaissances

Organic Chemistry

Synthetic Methodology

Medicinal Chemistry

Biology

Formation

M2 in Organic Chemistry

Description du poste

Organisation/Company: UMR 261

Research Field: Chemistry, Biological sciences » Biology, Medical sciences

Researcher Profile: Recognised Researcher (R2), Leading Researcher (R4), First Stage Researcher (R1), Established Researcher (R3)

Country: France

Application Deadline: 30 Apr 2025 - 22:00 (UTC)

Type of Contract: Temporary

Job Status: Full-time

Offer Starting Date: 1 Oct 2025

Is the job funded through the EU Research Framework Programme? Not funded by a EU programme

Is the Job related to staff position within a Research Infrastructure? No

Offer Description

A project already funded by ED MTCI identified the first synthetic «hit» of an alkaloid non-developable as an antimalarial, tazopsin. The proposed thesis aims at a continuity of therapeutic development of this simplified and accessible «hit», already showing an activity ten times higher than the natural product. The planned approach is a combinatorial 96-well «click» chemistry diversification, followed by a biological evaluation and physicochemical optimization of «early leads». The most promising compounds will be developed by the organization "Medecine for Malaria Venture".

Minimum Requirements

1. Have an M2 (or equivalent) in "Organic Chemistry" (total synthesis, synthetic methodology, medicinal chemistry etc.).
2. Have a "Good" / "Very Good" mention in M2 (very important impact on the selection of applications by the ED).
3. Experience/interest in biology: the candidate must be able to complete a thesis at the interface on 2 Parisian poles (chemistry at the Faculty of Pharmacy, biological tests at the UPMC), geographically close and where he/she will be trained by expert teams and partners of R. DUVAL for 10 years.