Job offer

European Commission; France; Sur place; EUR 30 000 - 45 000; Plein temps

Résumé du poste

Une institution de recherche en biologie recherche un chercheur établi pour travailler sur l'évolution des voies de translocation des protéines et l'évolution du cycle de Calvin-Benson. Le candidat réalisera des analyses comparatives, supervisera des stagiaires, et devra posséder de solides connaissances en bioinformatique et en génomique.

Qualifications

• Connaissance générale en bioinformatique nécessaire.
• Fortes compétences en génomique comparative et évolution des génomes.
• Maîtrise de l'analyse de données NGS souhaitée.

Responsabilités

• Produire des bibliographies des complexes TIC/TOC et TOM/TIM.
• Effectuer des analyses phylogénétiques sur les enzymes CBC.
• Supervision des stagiaires M2 possible.

Connaissances

Bioinformatique

Génomique comparative

Analyse des données NGS

Biologie évolutive

Anglais scientifique

Génétique

Description du poste

Organisation/Company CNRS Department Photobiologie et Physiologie des Plastes et Microalgues Research Field Biological sciences » Botany Biological sciences Technology » Biotechnology Researcher Profile Established Researcher (R3) Country France Application Deadline 25 Jun 2025 - 23:59 (UTC) Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Sep 2025 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The objective of the present project is to retrace the comparative evolutionary analysis of canonical translocation pathways for mitochondria (TOM/TIM for translocase of the outer/inner membrane) and chloroplast (TOC/TIC for translocon on the outer/inner chloroplast membrane) through which proteins are imported into those organelles.

Within this evolutionary perspective, she/he will also revisit the evolution of the Calvin-Benson Cycle (CBC) towards an increase in its CO2-fixing activity. To this end, the candidate will infer ancestral sequences of the CBC enzymes, in order for experimentalists to design strains of two model organisms carrying these ancestral sequences, that will undergo directed evolution and be selected for their increased fitness. She/he will also analyze the mutational trajectories of the evolved strains.

- Produce an exhaustive bibliography of TIC/TOC, TOM/TIM complexes and bacterial translocons involved in antimicrobial peptide resistance.
– Trace the evolutionary and comparative history of these three protein systems
- Perform phylogenetic analyses on CBC enzymes
- Analyze the evolution of the genome structure of a microalgal population during an experimental evolution experiment
- Supervision of M2 trainees possible.

The work will be carried out in the UMR7141 host laboratory “Photobiology and Physiology of Plastids and Microalgae (P3M)”, headed by Dr. Angela Falciatore at the Institut de Biologie-Physico-chimique in Paris (http://www.ibpc.fr/UMR7141/en/home/ ). This laboratory, located in the heart of the Latin Quarter, employs just over 30 people, including 19 statutory members. It addresses key questions on the biology, evolution and ecology of microalgae, focusing on various model species (e.g. Chlamydomonas reinhardtii and Phaeodactylum tricornutum) and ecologically important phytoplankton species, studied using ecophysiological, biophysical, biochemical, genomic and genetic approaches.
The project will be performed under the supervision of Ingrid Lafontaine.

Skills/Knowledge:
- General knowledge of bioinformatics
- In-depth knowledge and strong experience in comparative genomics and genome evolution
- In-depth knowledge of NGS data analysis
- Knowledge of evolutionary biology
- Fluency in scientific English (reading and writing)
- Basic knowledge of genetics
Know-how:
- Design and implement experimental protocols
- Ability to analyze and report information (keep laboratory notebooks, prepare tables summarizing results, prepare oral presentations).
- Prepare articles for publication in international peer-reviewed journals
- Innovation, rigor and reliability in the execution of work.
- Organizational skills.
- Ability to work as part of a team