Job offer

European Commission; France; Sur place; EUR 30 000 - 40 000; Plein temps

Résumé du poste

Institut Curie recherche un postdoctorant en recherche sur le cancer pour travailler sur des projets concernant les tumeurs cérébrales pédiatriques. Le candidat idéal aura un doctorat en biologie, des compétences en biologie moléculaire, et une passion pour l'innovation en médecine. Ce poste offre une durée de 3 ans, avec un environnement dynamique et multidisciplinaire, et inclut des avantages tels qu'une restauration collective et une couverture santé complémentaire.

Prestations

Restauration collective

Remboursement des frais de transport jusqu'à 70%

Assurance santé complémentaire

Qualifications

• Doctorat avec expérience en biologie moléculaire et expérimentations in vivo.
• Connaissances en biologie du cancer et métabolisme appréciées.
• Compétences en culture cellulaire et biologie moléculaire requises.

Responsabilités

• Étudier les voies de signalisation et leur impact sur les facteurs de transcription dans le cancer.
• Utiliser des modèles murins pour la recherche sur les tumeurs cérébrales pédiatriques.
• Identifier les vulnérabilités moléculaires dans les cancers pédiatriques.

Connaissances

Biologie moléculaire

Biologie cellulaire

Expérimentation in vivo

Culture cellulaire

Analyse de données NGS

Formation

PhD en biologie

Description du poste

Organisation/Company Institut Curie - Research Center Department Administration Research Field Medical sciences » Cancer research Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Country France Application Deadline 15 Sep 2025 - 09:00 (Europe/Paris) Type of Contract Temporary Job Status Full-time Is the job funded through the EU Research Framework Programme? Horizon 2020 Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The hosting structure

Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital group and a Research Center of more than 1000 employees with a strong international representativeness.

The objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.

Context

Laboratory

The Pouponnot’s team investigates signaling pathways and their impact on transcription factors in cancer, employing a range of biochemical and functional experimental approaches both in vitro and in vivo. We have extensive expertise in the use of mouse models and have developed a strong research focus on pediatric brain tumors, particularly medulloblastoma, as demonstrated in our publications (Garancher et al., Cancer Cell , 2018; Morabito et al., EMBO Mol Med , 2019). Our group has established genetically engineered mouse models, patient-derived xenografts, and advanced radiobiology tools to study cancer, including pediatric brain tumors, especially medulloblastoma (MB). Current research efforts are focused on elucidating mechanisms of treatment resistance—especially to radiotherapy—and identifying actionable molecular vulnerabilities in pediatric brain cancers.

Medulloblastoma (MB) is a pediatric tumor of the cerebellum, which represents the most frequent malignant brain tumor in childhood. It is classified into four subgroups: WNT, SHH, group 3 (G3) and group 4. G3 has the poorest prognosis and is associated with a high rate of metastasis and a high probability of relapse. Mechanisms and transcription factors (TFs) that drive its initiation, maintenance, therapeutic resistance and metastatic potential are poorly characterized. Here, we propose to investigate the role of a TF recently identified as a major regulator of the G3 signature. The project focuses on the understanding of its role in G3-MB at the molecular level (RNAseq, ChIPSeq, CRISPR Screen (TF network)…), cellular level (proliferation, protection against apoptosis, migration…) and in tumor progression (in vivo orthotopic grafting).

Contraints ( to be cancelled if not necessary)

• work outside regular working days (in vivo experiments)

Candidate Profile

Training and Skills required

• Training: PhD with strong experience in molecular and cellular biology as well as in vivo experiments.Knowledge in cancer biology and in metabolism will be appreciated.
• Scientific skills: Cell culture (cell lines and primary cells)/ In vivo mouse experiment/ molecular biology (Cloning, CRISPR, RNA DNA preparation…) / Biochemistry (WB, IP, ChIPSeq…)
• Language skills:ability to write and communicate in English

Desirable Knowledge, skills and abilities:

• Preferably with experiences in 3D cell culture and primary cell culture
• Competence in basic NGS data analyses and statistical methods is a strong merit but not required.
• Scientific rigor
• Excellent analytical and synthetic capabilities
• Well organised, ability to work independently
• a high team spirit
• Dynamic personality with passion for innovation and problem-solving
• A will to work in a multidisciplinary environment
• Ability to communicate

All our opportunities are open to people with disabilities

Contract information

Type of contract: Fixed-term contract.

Duration: 3 years

Working time: full time

Remuneration: according to the current grids of the Institut Curie and to the experience of the candidate

Benefits : Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance

Location of the position: Paris – Orsay – Saint-Cloud

Institut Curie is an inclusive, equal opportunity employer and is dedicated to the highest standards of research integrity.