Job offer

European Commission; France; Sur place; EUR 40 000 - 60 000; Plein temps

Résumé du poste

Le Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques propose un poste de doctorant sur un projet innovant en chimie. Le candidat retenu se concentrera sur le développement de nouveaux photocatalyseurs à base de paracyclophanes, avec des applications dans la chimie organique et la photocatalyse. Cette opportunité unique permettra une collaboration entre deux laboratoires prestigieux en France et offrira un environnement de recherche dynamique.

Qualifications

• Accès à un Master en Chimie ou un domaine pertinent.
• Connaissance de la photocatalyse et de la chimie des matériaux appréciée.
• Capacité à travailler sur des projets de recherche innovants.

Responsabilités

• Réaliser des travaux de recherche sur les photocatalyseurs à base de pCp.
• Développer des procédés plus efficaces dans le cadre de la thèse de doctorat.
• Collaborer avec d'autres chercheurs sur des projets interuniversitaires.

Connaissances

Synthèse organique

Chimie des matériaux

Photocatalyse

Chiralité

Formation

Master en Chimie ou domaine connexe

Description du poste

Organisation/Company CNRS Department Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques Research Field Chemistry Environmental science Researcher Profile First Stage Researcher (R1) Country France Application Deadline 11 Jul 2025 - 23:59 (UTC) Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Oct 2025 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

This position is part of a project funded by the French National Research Agency (ANR), involving a collaboration between two chemistry laboratories: the Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques (LCPBT, UMR 8601, Paris Cité University) and the Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO, UMR CNRS 8182, Paris-Saclay University).
The PhD candidate will primarily carry out their research at the Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques (UMR 8601, CNRS, Université Paris Cité, Paris 6th arrondissement), within the host team "New Synthetic Methods for the Chemistry–Biology Interface." The team's research encompasses a broad spectrum of topics in synthetic organic chemistry and chemical biology, with a particular emphasis on molecular innovation.

[2.2]Paracyclophanes (pCps) are fascinating molecules with an unusual three-dimensional structure and intriguing physicochemical properties.[1] These compounds have been extensively used in material science as building blocks for through-space conjugated polymers and optoelectronic devices.[2] Owing to their planar chirality, pCps have also found numerous applications as ligands in asymmetric catalysis.[3] However, their use as organocatalysts remains relatively limited.[4] The development of novel processes promoted by these compounds would represent a significant advancement in cyclophane chemistry.
Photocatalysis is a fascinating field of research that harnesses light as an energy source to drive organic transformations. Over the years, various catalysts - both fully organic compounds and metal-based complexes - have been developed to reinvent known reactions or enable previously inaccessible ones.[5] However, controlling chirality in light-induced transformations remains a significant challenge.
In our laboratory, pCp derivatives have been successfully utilized as organophotocatalysts to promote different reactions under light irradiation.[6] In a recent collaboration with Dr. Thomas Boddaert (Université Paris-Saclay), we demonstrated that chirality control in the thio-Paternò–Büchi reaction[7] can potentially be achieved using our planar chiral photocatalysts.[8] The aim of this PhD thesis is to develop new, more efficient pCp-based photocatalysts by functionalizing their aromatic rings with various groups. This approach will build on our promising preliminary results to achieve more effective asymmetric thia-Paternò–Büchi reactions. A potential extension of this work also involves the development of circularly polarized light emitters, thereby opening the way to applications in other research fields
References: (1) Brown, C. J.; Farthing, A. C. Nature 1949, 164, 915. (2) Hassan, Z.; Lahann, J.; Bräse, S. Adv. Funct. Mater. 2024, 2410027. (3) Gibson, S. E.; Knight, J. D. Org. Biomol. Chem. 2003, 1, 1256. (4) Felder, S.; Wu, S.; Brom, J.; Micouin, L.; Benedetti, E. Chirality 2021, 33, 506. (5) Shaw, M. H.; Twilton, J.; MacMillan, D. W. C. J. Org. Chem. 2016, 81, 16, 6898. (6) Brom, J.; Maruani, A.; Turcaud, S.; Lajnef, S.; Peyrot, F.; Micouin, L.; Benedetti, E. Org. Biomol. Chem. 2024, 22, 59. (7) Lapuh, M. I.; Cormier, G.; Chergui, S.; Aitken, D. J.; Boddaert, T. Org. Lett. 2022, 24, 8375. (8) Unpublished preliminary results.