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The European Commission is offering a full-time research position in organic chemistry focused on asymmetric catalysis at the ICSN. The candidate will conduct innovative research to optimize catalytic processes, requiring a Master's degree in organic chemistry and relevant laboratory experience.
Organisation/Company CNRS Department Institut de Chimie des Substances Naturelles Research Field Chemistry Environmental science Researcher Profile First Stage Researcher (R1) Country France Application Deadline 1 Jul 2025 - 23:59 (UTC) Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Oct 2025 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No
This thesis will be carried out at the ICSN, in the Chemistry of Phosphorus and Catalysis team, under the responsibility of a CNRS researcher. The student will be able to take advantage of all the appropriate scientific and technical environment, in order to carry out his research in the best possible way.
Supramolecular regulation of chiral ligands for asymmetric gold(I) catalysis. The control of stereoselectivity in homogeneous catalysts is most often achieved by modifying the microenvironment around the metal center by introducing appropriate substituents on chiral ligands, near the latter. For example, in the case of gold catalysis involving C1-symmetric ligands, the main objective is to have the best possible «chiral pocket». Unfortunately, to achieve this goal, it is often necessary to synthesize dozens of catalysts with different steric and/or electronic properties.
In the framework of this thesis project, we propose a new strategy to effectively modulate the second coordination sphere of a metal center, through hydrogen bonds established between the skeleton of a modulable chiral ligand and complementary achiral additives. This strategy should allow us to optimize a catalytic process quickly.
Candidate wanted: Master's degree in organic chemistry (or equivalent degrees), laboratory experiment in organic synthesis and/ or catalysis.