Job offer

European Commission; France; Sur place; EUR 22 000 - 30 000; Plein temps

Résumé du poste

Une prestigieuse organisation de recherche en France propose un poste de doctorant. Le projet portera sur l'étude des mécanismes de transmission du VIH-1 et nécessite des compétences en virologie. Les candidats doivent avoir un Master en biologie cellulaire et moléculaire et être motivés pour travailler en équipe sur des projets multidisciplinaires.

Qualifications

• Doit avoir un Master en biologie cellulaire et moléculaire.
• Bonnes connaissances en manipulation des agents infectieux.
• Autonomie et motivation dans le développement de compétences en virologie.

Responsabilités

• Caractériser les facteurs cellulaires impliqués dans le mécanisme de fusion cellulaire.
• Collaborer avec des équipes multidisciplinaires.
• Présenter et écrire des articles pour des revues scientifiques.

Connaissances

Connaissances en virologie

Communication orale et écrite

Travail en équipe

Formation

Master en biologie cellulaire et moléculaire

Description du poste

Organisation/Company CNRS Department NAnomédecine, Biologie extracellulaire, Intégratome et Innovations Research Field Biological sciences Medical sciences Pharmacological sciences Researcher Profile First Stage Researcher (R1) Country France Application Deadline 1 Jul 2025 - 00:00 (UTC) Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Oct 2025 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The PhD student will be affiliated to the BioSPC Doctoral School, Department of infectiology/microbiology from the University Paris Cité. The project will be developed under the supervision of Dr. Serge Benichou within the NABI Unit (CNRS UMR8175, Inserm U1334, Université Paris Cité) headed by Dr. Florence Gazeau. This thesis will be carried out in close collaboration with Dr Christel Vérollet's team (IPBS, CNRS UMR 5089, Université de Toulouse). Serge Benichou's research group already has all the required infrastructures (including a laboratory dedicated to the manipulation of class 3 infectious agents, BSL3, such as HIV-1) and biological reagents. The funding of the experiments will be saved by the fundings obtained by Serge Benichou on this project.

The general goal of the scientific project is to characterize the cellular factors involved in the cell-cell fusion mechanism involved in the transfer and dissemination of HIV-1 from infected CD4 T lymphocytes to myeloid macrophage target cells, leading to the formation of virus-producing multinucleated giant cells. This thesis will be carried out in close collaboration with Dr Christel Vérollet's team (IPBS, CNRS UMR 5089, Université de Toulouse). This thesis should provide important insights into the role of infected macrophages in viral transmission and dissemination, as well as in the establishment of persistent viral tissue reservoirs in HIV-1-infected patients.

The candidate must hold a Master's degree in Cellular and Molecular Biology. The position requires good knowledges in virology, and in particular on HIV-1 and its handling in BSL3 Laboratory. Good oral and written communication skills (French and English required) to present at conferences and write articles for scientific journals. We are looking for a young researcher who is highly motivated for the development of this project, curious, with a degree of autonomy and a strong motivation to develop virology skills in the field of the mechanisms regarding the intercellular dissemination of HIV-1 to macrophages. Candidates should also be able to work in a team on multidisciplinary projects.
Applications should include: 1) a detailed CV with letters from 2 referees who have followed the candidate's academic career; 2) a one-page motivating cover letter.
The deadline for application is June 30th 2025.