Job offer

European Commission; France; Sur place; EUR 35 000 - 50 000; Plein temps

Résumé du poste

Le CNRS recherche un Professeur Junior pour diriger des recherches en chimie axées sur les thérapies personnalisées et les nanoparticules, dans le cadre d'un projet innovant aligné avec les objectifs du plan France 2030. Le candidat sélectionné sera impliqué dans des programmes d'enseignement et contribuera à la recherche au sein de plusieurs laboratoires renommés.

Qualifications

• Docteur ou candidat ayant acquis un diplôme équivalent.
• Expérience en recherche interdisciplinaire souhaitée.
• Connaissances en matériaux nanométriques appréciées.

Responsabilités

• Développer et valider de nouveaux matériaux nanoporeux pour applications biomédicales.
• Participer à des programmes d'enseignement à l'Université de Caen Normandie.
• Contribuer à des publications scientifiques et des projets de recherche.

Connaissances

Recherche en chimie

Recherche en biologie

Savoir-faire en nanomatériaux

Formation

Doctorat ou diplôme équivalent

Description du poste

Organisation/Company CNRS Department Direction des ressources humaines Research Field Pharmacological sciences Engineering Technology Researcher Profile First Stage Researcher (R1) Country France Application Deadline 14 Jul 2025 - 23:59 (UTC) Type of Contract Other Job Status Full-time Hours Per Week 35 Offer Starting Date 23 Jun 2025 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The CNRS is at the forefront of international research, notably due to its ability to foster breakthrough research through interdisciplinarity. The proposed Junior Professorship, based on two CNRS institutes, CNRS Biology and CNRS Chemistry, is fully in line with the CNRS mission to ensure the advancement of knowledge in all disciplinary fields, and here more particularly in the fields of innovation in chemistry for tomorrow's health applications. In its 2019-2023 contract of objectives, the CNRS has highlighted the growing demand for multifunctional materials, with optimized, combined or even extraordinary properties. The program proposed through this Junior Professorship is perfectly in line with this objective. Indeed, with the advent of 5P medicine, offering (nano)-molecules that can be custom-modulated according to a patient's intrinsic characteristics is a major challenge, and only multidisciplinary research will enable us to achieve this goal.
As part of the France 2030 plan, the objectives are to position France among the leaders in a dozen strategic sectors such as energy, health of the future, decarbonization of industry, food and agriculture... The research program presented here is a perfect response to this health of the future objective, with the development of theranostic objects based on the research of the two CNRS laboratories (ISTCT and LCS) hosting this Junior Professorship.

ISTCT seeks to better understand the pathophysiology of hypoxic tumors (brain-lung-brain metastases), to identify new therapeutic strategies targeting the tumor and its microenvironment, and to assess the effects of anti-cancer treatments including radiotherapy (RT) on healthy tissues and their protection, using in vivo imaging (MRI, PET/CT) in particular. For several years now, ISTCT has been working on a nano-particle approach targeting tumor cells, in partnership with the LCS laboratory. The LCS is an internationally renowned laboratory in the field of nano-zeolite synthesis. The functionalization of these nanoparticles enables them to be used as carriers for sensitizing agents targeting cancer cells.
Collaboration between the 2 partners through this position will enable us to refine this nano-particle therapy strategy to combine various components (in particular by taking into account the tumor microenvironment) with the overall aim of offering a multimodal tumor targeting platform that can be adapted to suit individual needs. The Junior Professorship will enable the laboratory to strengthen its original research into intelligent, customizable chemistry tools, in order to offer innovative therapeutic and imaging (theranostics) tools.

The main objective of the project is to custom-synthesise and validate in vivo new nanometric porous materials (zeolites) for biomedical applications. Nanozeolites are nanoparticles whose synthesis and ability to adsorb and deliver guest molecules can be perfectly controlled in a physiological context at a defined pH. The project focuses on 1) the development and validation of new biocompatible nanometric zeolites without organic materials and 2) their use in preclinical models to improve the efficacy of conventional treatments for brain tumours or other resistant tumours. In particular, hypoxia-induced radiation and chemoresistance, as well as other phenomena associated with tumour growth such as inflammation, will be targeted. There are more than 250 known zeolites. The new challenge for a project focusing on chemistry will be to control their properties through synthesis design in order to improve performance in terms of stability, selectivity and biocompatibility. For a biology-based project, therapeutic uses and multimodal imaging monitoring in relevant models will be proposed. These new compounds combined with the advanced characterisation and vectorisation of the molecules determined for biomedical applications constitute the ultimate interdisciplinary objective, with the aim of providing a theranostic platform adaptable to the biomedical context.

The activities of the recruited candidate will be part of the teaching programs at the University of Caen Normandy, through educational contributions in the field of chemistry–biology related to health. Depending on the candidate's profile, these activities may be developed within the departments of Chemistry or Biology.

The CNRS is developing a strong policy in favor of open science. Open science consists of making research results "as accessible as possible and closed as necessary". As such, the CNRS aims to make 100% of the texts of publications resulting from the work of its laboratories accessible , in particular through deposit in HAL. The data produced must also be made available and reusable, except for specific restrictions. In addition, the guiding principles of individual evaluation have been revised in accordance with the DORA declaration, to be more qualitative and to take into account all facets of the researcher's profession.

The dissemination of the results will be done through world-class scientific productions: publications, patents, software... In addition, the results will be communicated to various targets such as scientific communities, media, decision makers, general public, schools, etc., with an adapted calendar. Specific tools may be developed such as websites, newsletters, meetings, international symposia, summer schools and conferences.

The relationship between science and society is now recognized as a full dimension of scientific activity. The project will develop this dimension in synergy with all the partners. The resulting research work will contribute to informing public decision-making. Participatory science initiatives may be initiated with actors from the project's socio-economic and cultural eco-system.

holders of a doctorate or a PhD or equivalent degree or applicants who have gained scientific. There is no restriction on the age or nationality of applicants. All CNRS positions are accessible to people with disabilities, with special arrangements for tests made necessary by the nature of the disability.