Job offer

European Commission; France; Sur place; EUR 35 000 - 45 000; Plein temps

Résumé du poste

Une institution de recherche renommée en France cherche un chercheur postdoctoral pour le projet CholinOA, axé sur les voies cholinergiques impliquées dans la douleur liée à l'ostéoarthrite. Le poste implique de la recherche expérimentale à Paris et Valbonne, ainsi qu'une interaction avec des équipes multidisciplinaires. Un doctorat en biologie ou discipline connexe est requis, ainsi qu'une expérience dans l'expérimentation animale.

Qualifications

• Doctorat en biologie, neuroscience ou immunologie.
• Expérience en modèles murins d'ostéoarthrite.
• Accréditation pour expérimentation animale au niveau 1.

Responsabilités

• Développement de modèles murins d'ostéoarthrite.
• Analyse histologique et expérimentations cellulaires.
• Travail collaboratif entre Paris et Valbonne.

Connaissances

Expérience en expérimentation animale

Surgery murine

Histologie

Biologie moléculaire

Formation

PhD en biologie, neuroscience ou immunologie

Description du poste

Organisation/Company Sorbonne Université Research Field Biological sciences » Biology Medical sciences Researcher Profile Recognised Researcher (R2) Established Researcher (R3) Country France Application Deadline 15 Jul 2025 - 22:00 (UTC) Type of Contract Temporary Job Status Full-time Offer Starting Date 1 Sep 2025 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

We are seeking a highly motivated postdoctoral researcher to join the ANR-funded CholinOA project, which aims to investigate neuronal and non-neuronal cholinergic pathways involved in osteoarthritis-related pain and inflammation.

Main responsibilities

The candidate will carry out experimental work primarily in Paris (UMRS_938, Sorbonne Université, Saint-Antoine Research Centre) with regular travel to Valbonne (Université Côte d’Azur / CNRS, Institut de Pharmacologie Moléculaire et Cellulaire), including:

Development and monitoring of murine models of osteoarthritis:

Surgical model: destabilisation of the medial meniscus (DMM)

Chemical models: intra-articular injection of collagenase (CIOA) or monoiodoacetate (MIA)

Performing vagotomies and implantation of electrodes for vagus nerve stimulation (VNS)

Tissue collection and processing (joints, lymph nodes, spleen, dorsal root ganglia)

Histological analysis (Safranin O / H&E staining, multichannel immunohistochemistry)

Cellular and molecular biology experiments: RNA extraction, RT-qPCR, ELISA, immunofluorescence

Contribution to the analysis of pain, inflammation, and cholinergic activity markers

Candidate profile

PhD in biology, neuroscience, immunology or a related discipline

Proven experience in animal experimentation using murine models of osteoarthritis or inflammatory diseases

Valid authorisation for animal experimentation at level 1 (designing procedures)

Skills in murine surgery, histology, tissue processing, and molecular biology

Ability to work independently and collaboratively within a multidisciplinary team

Willingness to travel between Paris and Valbonne

PhD in biology, neuroscience, immunology, or a related field

Proven experience in animal experimentation using murine models of osteoarthritis or inflammatory diseases

Mandatory accreditation for animal experimentation at designing level (Level 1)

Proficiency in murine surgery, histology, tissue processing, and molecular biology

Ability to work independently and collaboratively within a multidisciplinary research team

Willingness to travel between the research sites in Paris and Valbonne