Job offer

European Commission; France; Sur place; EUR 30 000 - 38 000; Plein temps

Résumé du poste

L'Institut de Génétique Moléculaire de Montpellier recrute un chercheur en biologie pour travailler sur le rôle des structures ADN dans l'expression génique. Le candidat idéal possèdera une formation solide en biologie moléculaire ou en bioinformatique, et travaillera sur des techniques innovantes en collaboration avec une équipe de recherche spécialisée.

Qualifications

• Expérience en biologie moléculaire, génomique fonctionnelle ou bioinformatique.
• Motivé(e) et enthousiaste.

Responsabilités

• Conduire des recherches sur le rôle des structures d'ADN.
• Utiliser des approches de génomique fonctionnelle et techniques d'édition de génome.

Connaissances

Biologie moléculaire

Génomique fonctionnelle

Bioinformatique

Description du poste

Organisation/Company CNRS Department Institut de génétique moléculaire de Montpellier Research Field Biological sciences » Biology Researcher Profile First Stage Researcher (R1) Country France Application Deadline 17 Jun 2025 - 23:59 (UTC) Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Oct 2025 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The student will be supervised by Jean-Christophe Andrau at the Institut de Génétique Moléculaire de Montpellier (IGMM), and will have access to a number of technological platforms. He/she will also have the opportunity to train in bioinformatics in the laboratory and in a workshop organized by the laboratory. We are looking for a motivated and enthusiastic candidate with solid experience in at least one of the following areas: molecular biology, functional genomics, bioinformatics, as well as good knowledge of chromatin and eukaryotic transcription.

Secondary DNA structures, alternative to the double helix, not only play a role in DNA topology but are also likely to play a regulatory and functional role in mammalian genomes. This is particularly true for G-quadruplexes (G4s), which form stable single-stranded DNA in vitro. Our laboratory has recently shown that these structures are important for gene expression at the promoter level by promoting chromatin opening, in particular through the use of a new technique enabling them to be mapped in cellular context. The aim of this thesis is to highlight the role of G4s in the insulation of chromatin domains. It will test the hypothesis that G4s can help separate topological domains or active and inactive domains of chromatin. To do this, functional genomics approaches as well as genome editing techniques will be used. This work will be carried out in collaboration with a team in Gif-sur-Yvette specialized in the study of insulation.