Job offer

European Commission; France; Sur place; EUR 25 000 - 30 000; Plein temps

Résumé du poste

A leading research laboratory in France is seeking a PhD candidate to explore regulatory mechanisms in renal intercalated cell function. The project focuses on understanding how these cells maintain acid-base balance, which is crucial for various biochemical processes. Candidates with a background in Biomedical Sciences and experience in relevant techniques are encouraged to apply.

Qualifications

• Background in Biomedical Sciences or related fields required.
• Experience with mouse models and mammalian cell culture is an asset.

Responsabilités

• Investigate regulation of acid-base balance in renal intercalated cells.
• Characterize intracellular mechanisms activating bicarbonate secretion.

Connaissances

Biomedical Sciences

Renal Physiology

Formation

Master's Degree

Outils

Microscopy

Description du poste

Organisation/Company: CNRS

Department: Laboratoire de Biologie Tissulaire et d'Ingénierie Thérapeutique

Research Field: Biological sciences

Researcher Profile: First Stage Researcher (R1)

Country: France

Application Deadline: 4 Jun 2025 - 23:59 (UTC)

Type of Contract: Temporary

Job Status: Full-time

Hours Per Week: 35

Offer Starting Date: 1 Oct 2025

Funding: Not funded by a EU programme

Research Infrastructure Staff Position: No

Offer Description

The Laboratory of Tissue Biology and Therapeutic Engineering (LBTI, UMR 5305) operates under the joint supervision of the CNRS and Claude Bernard University Lyon 1 (UCBL1). The laboratory is distributed across three locations and comprises about 120 members including researchers, PhD students, postdocs, and technical staff. More information is available at: https://lbti.ibcp.fr.

The unit's research focuses on healthy and pathological tissues and developing therapeutic strategies with clinical potential. The management team is based at the Gerland campus, with laboratories across three sites.

The PhD candidate will join the SKIN team within the LBTI, supervised by Dr. Nicolas Picard, as part of the Sense-pH project funded by the ANR.

PhD Project: Regulatory Mechanisms in Renal Intercalated Cell Function

This project investigates the regulation of acid-base balance in humans, focusing on renal intercalated cells (ICs). Maintaining blood pH is vital for biochemical reactions and oxygen transport. Dysfunctions in α-ICs and β-ICs can cause renal tubular acidosis or metabolic alkalosis.

The objectives include understanding signaling pathways involved in the kidney's response to pH and electrolyte changes, especially alkalosis. The main goal is to characterize intracellular mechanisms activating bicarbonate secretion during metabolic alkalosis in β-ICs.

Requirements for applicants include holding a master's degree or being enrolled in a master's program ending in 2025, with a background in Biomedical Sciences or related fields, and an interest in renal physiology. Experience with mouse models, animal experiment authorization, mammalian cell culture, and microscopy are assets. The candidate will enroll in the doctoral school EDISS 205, with specific selection criteria available at: https://ediss.universite-lyon.fr/candidater-au-doctorat/candidature-edi….