Job offer

European Commission; France; Sur place; EUR 35 000 - 45 000; Plein temps

Résumé du poste

Une opportunité de postdoctorat à l'Institut Pasteur de Paris pour étudier les canaux ioniques à l'aide de techniques avancées comme la fluorométrie à clamp de tension. Le candidat travaillera sur des projets innovants dans un environnement scientifique dynamique, avec une possibilité de renouvellement du contrat.

Qualifications

• Expérience en électrophysiologie et simulations dynamiques.
• Compétences en techniques de fluorescence souhaitées.
• Capacité à travailler en autonomie et en équipe.

Responsabilités

• Analyse fonctionnelle-structure des canaux ioniques par électrophysiologie.
• Développement de techniques d'étiquetage fluorescent innovantes.
• Collaboration avec des biologistes structuraux.

Connaissances

Electrophysiologie

Biologie moléculaire

Modélisation moléculaire

Formation

Doctorat en biologie, biophysique, biochimie ou pharmacologie

Description du poste

Organisation/Company: CNRS
Department: Gènes, synapses et cognition
Research Field: Physics
Researcher Profile: First Stage Researcher (R1)
Country: France
Application Deadline: 11 Jul 2025 - 23:59 (UTC)
Type of Contract: Temporary
Job Status: Full-time
Hours Per Week: 35
Offer Starting Date: 1 Oct 2025
Is the job funded through the EU Research Framework Programme? No
Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Postdoctoral position on “Investigation of pentameric ligand-gated ion channels by Voltage-Clamp fluorometry”. The signalization and receptor dynamics group of the Institut Pasteur in Paris is seeking highly motivated candidates for a postdoctoral position in electrophysiology to perform structure-function analysis in real time.

The successful candidate will be recruited for 12 months (renewable several times) funded by CNRS.

The position involves voltage-clamp fluorometry to monitor ion channel gating by electrophysiology and protein motions by fluorescence in physiological conditions. The project aims to develop innovative fluorescent labeling techniques, including new dyes or unnatural amino acids, to create conformational sensors. It will also involve molecular biology, protein biochemistry, and molecular modeling such as molecular dynamic simulations.

The work will be conducted in the “Signalization and Receptors Dynamics” team under the supervision of Pierre-Jean Corringer. The team is part of the CNRS unit “Genes, Synapses and Cognition” and the neuroscience department of the Institut Pasteur. The Institut Pasteur of Paris offers a dynamic scientific environment in the heart of Paris. The lab studies the structure and function of pentameric ligand-gated ion channels, focusing on structural bases of gating and regulation by small molecules. Projects combine structural techniques with functional approaches, including biochemistry, crystallography, pharmacology, and electrophysiology, all supported by fully equipped facilities. More info: https://research.pasteur.fr/en/team/signaling-and-receptors-dynamics/

Applicants should have a degree in biology, biophysics, biochemistry, or pharmacology, with doctoral experience in electrophysiology and molecular dynamic simulations. Prior experience in voltage-clamp fluorometry and fluorescence techniques is advantageous. The candidate should be able to work independently and collaboratively within an interdisciplinary environment, especially with structural biologists.