Job offer

Sorbonne University; France; Sur place; EUR 40 000 - 80 000; Plein temps

Résumé du poste

Une institution de recherche de premier plan recherche un professeur junior en immunologie systémique pour rejoindre son laboratoire innovant. Ce poste passionnant implique le développement de modèles computationnels avancés pour explorer les mécanismes sous-jacents des maladies auto-immunes. Le candidat idéal aura une solide expérience en immunologie et en bioinformatique, et jouera un rôle clé dans la formation de la prochaine génération de chercheurs. En rejoignant cette équipe dynamique, vous contribuerez à des projets de recherche de pointe et à la formation de futurs leaders dans le domaine de la biologie et de la santé.

Qualifications

• Forte expérience en immunologie et technologies omiques.
• Compétences en biologie cellulaire et moléculaire ou en biologie computationnelle.

Responsabilités

• Proposer des projets innovants pour identifier des biomarqueurs.
• Contribuer à la formation de jeunes scientifiques et médecins.

Connaissances

Immunologie

Bioinformatique

Analyse de données

Langages de programmation (Python, C++)

Biostatistique

Formation

PhD ou équivalent

MSc

Outils

R

Outils d'analyse de données

Description du poste

Organisation/Company: Sorbonne University

Department: Faculty of Medicine

Research Field: Computer Science » Other

Researcher Profile: Established Researcher (R3)

Positions: Postdoc Positions

Country: France

Application Deadline: 31 Jul 2025 - 12:30 (Europe/Paris)

Type of Contract: Temporary

Job Status: Full-time

Is the job funded through the EU Research Framework Programme? Not funded by a EU programme

Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Strategy of the host institution: INSERM, one of the leading biomedical research institutions in Europe and worldwide, is driven by the international dynamics of research in biology and health to delve into increasingly complex questions. This exploration requires the utilization of multidisciplinary approaches that encompass various scientific disciplines and technological expertise. Consequently, INSERM has made the recruitment of innovative profiles a key objective in its strategic plan, aiming to foster groundbreaking advancements. In line with this objective, the proposed recruitment of a junior professorship position at the i3 Laboratory perfectly aligns with INSERM's vision. The institution seeks to recruit a candidate who can harness cutting-edge approaches to advance our understanding of autoimmune diseases and push the boundaries of knowledge in immunology. In addition to contributing to these objectives, the junior professor will play a role in training young scientists and medical doctors through the Systems Immunology training program at Sorbonne Université.

Strategy of the host laboratory: The i3 Laboratory has been developing a translational systems immunology approach in the field of autoimmune and inflammatory diseases (AID) for over 10 years. Established collaborations with various clinical services (internal medicine, rheumatology, diabetology and the Biotherapies clinical investigation center) affiliated to AP-HP and Sorbonne Université, the multidisciplinary composition of the team (biologists, immunologists, clinicians, informaticians, and bioinformaticians) and the numerous major national and european fundings (LabEx and RHU by Investissement d’Avenir, Agence Nationale pour la Recherche; ERC Advanced and H2020) have been pivotal to this expertise development.

The laboratory has generated unique massive multiparametric datasets, representing an investment of over 10 million euros for their generation, that describe the immune systems of more than 900 patients with one AID, recruited under observational or interventional clinical trials.

I3’s personnel involved in systems immunology has grown from 5 members (with 2 permanent PIs) to now 15 members (including 5 permanent members (4 PIs and 1 assistant engineer). To maximize the exploitation and valorization of this investment, the i3 lab aims at recruiting a junior professor with expertise in systems immunology to introduce innovative ideas and propel the research forward.

Summary of the scientific project: The proposed junior professorship position at the i3 Laboratory will be seamlessly integrated into the research and training endeavors of the laboratory and affiliated institutions. The primary objective for the candidate will be to propose innovative projects aimed at identifying biomarkers and novel therapeutic targets through either the development of advanced computational models and algorithms to uncover fundamental mechanisms underlying immune system dysregulation or the design of translational research projects aimed at testing and validating new therapeutic strategies. A central aspect of this role will involve building upon the extensive datasets already generated by the i3 Laboratory.

These datasets include comprehensive immunophenotyping of blood cells, full transcriptome and T-cell receptor repertoires of regulatory T-cells, effector T-cells, and CD8 T-cells, as well as gut microbiome data from a cohort of 900 patients with autoimmune and inflammatory diseases and healthy volunteers. Additionally, meticulous metadata containing accurate clinical descriptions of the patients are available.

Candidate Requirements: Candidate should possess a strong background in Immunology and substantial professional experience with state-of-the-art omics technologies together with experimental skills in cellular and molecular biology or in modeling and computational biology.

Summary of the teaching project: The rise of integrated approaches and technological advancements necessitates interdisciplinary training for the next generation of researchers in biology, modeling, and bioinformatics. Within the i3 Laboratory, a team of members has spearheaded the establishment and coordination of the pioneering Systems Immunology training program at Sorbonne Université.

This program is integrated into the third year of the Bachelor's degree (Unit of Teaching LU3SV648: Big data in biology - public health challenges) and the second year of the Master's degree in Molecular and Cellular Biology, specializing in Immunology through the Integrative and Systems Immunology master 2 track. The training program covers various essential aspects, including innovative omics’ technologies, modeling, analysis of complex data, and bioinformatics. Annually, approximately 50 students from scientific, pharmaceutical, and medical backgrounds enroll in these programs. Innovative pedagogical approaches such as project-based learning and autonomous learning strategies are employed. The junior professor's expertise will contribute to the continued improvement and innovation of the training program, through lectures and workshops, ensuring that students receive cutting-edge knowledge and skills in Systems Immunology.

Funding: The i3 lab offers a well-established environment enabling the processing and analysis of the data belonging to the project. For the first period of 3 years, Master 2 students (1 per year) will be recruited.

Scientific communication and dissemination: The candidate will be expected to present his/her results during major French and international immunology congresses, including the annual SFI and FOCIS meetings. The candidate will submit his/her results to peer-reviewed journals.

Open Science: The i3 lab is well-aligned with the open-science principle. As such, posters, abstract and research article will be submitted to the HAL platform from our national institutions. All the research articles are currently submitted to well-established journals with open-science policies.

Finally, all the data and computational tools will be submitted to dedicated databases and platforms to support sharing to the scientific community, in agreement with the GDPR regulation policies regarding human data.

Science and society: The i3 lab is involved, through its clinical component, in various patient associations. As such, the results of the project will benefit from opportunities to disseminate discoveries and novel methodology with interest for the patient through dedicated meetings.

Where to apply

E-mail: [e-mail]

Requirements

Research Field: Communication sciences » Science communication

Education Level: PhD or equivalent

Skills/Qualifications: A MSc or PhD is required in either bioinformatics, biostatistics, statistics, mathematics, computer science or immunology. Significant experience with R tools and coding languages (Python, C++), as well as high throughput data analysis, management and integration are required.