Job offer

European Commission; France; Sur place; EUR 40 000 - 60 000; Plein temps

Résumé du poste

Le CNRS IEMN à Lille offre une bourse doctorale dans le cadre du projet 'DNASTRIX', axé sur l'étude des interactions mécaniques au sein des cellules et leurs implications génomiques. Le candidat idéal aura une formation solide en physique ou en biophysique, et s'intéressera aux nouvelles techniques de recherche. Ce projet innovant et de pointe promet des découvertes majeures dans le domaine de la science des matériaux et du cancer.

Prestations

Bourse doctorale financée

Accès à des équipements de pointe

Collaboration interdisciplinaire

Qualifications

• Expérience en modélisation théorique et en biophysique nécessaire.
• Doit posséder un doctorat en physique ou un domaine connexe.
• Connaissances en microsystèmes et imagerie de fluorescence appréciées.

Responsabilités

• Etudier et quantifier les mécanismes nucléaires influencés par des forces externes.
• Observer la réorganisation de la chromatine et le dommage ADN lié aux forces mécaniques.

Connaissances

Modélisation théorique

Microsystems Engineering

Fluorescence Imaging

Mécanique cellulaire

Biophysique

Formation

Doctorat en physique ou biophysique

Description du poste

Organisation/Company CNRS Department Institut d'électronique, de microélectronique et de nanotechnologie Research Field Chemistry » Physical chemistry Physics » Chemical physics Physics » Biophysics Researcher Profile First Stage Researcher (R1) Country France Application Deadline 11 Jul 2025 - 23:59 (UTC) Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Sep 2025 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The CNRS IEMN institute in Lille (Hauts-de-France) brings together in a single structure the bulk of regional research in a vast scientific field ranging from the physics of materials and nanostructures to telecommunications systems and acoustic and microwave instrumentation. The IEMN Physics group studies thin films, hetero and periodic structures, individual or assembled biomolecules and 0D/1D/2D materials of great interest for technological breakthroughs in electronics, optics, acoustics, optoelectronics and nanotechnology. The NAMASTE team of the Physics group develops theoretical and experimental subjects of soft matter, biophysics and micro-physics of cancer.

The DNASTRIX project aims to study and quantify how nuclear mechanics can be modified by forces originating from the cellular environment, and what are the key genomic implications of these mechanical processes, potentially involved in many human diseases, from the cellular to the molecular scale. To achieve such ambitious goals, we are pushing the boundaries of a set of innovative techniques based on micro-electromechanical systems (MEMS) devices, under active development in our laboratories, thanks to which we can apply controlled forces both to molecular aggregates [1], and to whole living cells, while performing real-time fluorescence and confocal imaging [2]. In parallel, we are exploiting a program for all-atom, coarse-grained theoretical and computational molecular dynamics (MD) modeling of key proteins participating in mechanical actions transmitted to the nucleus and chromatin from the cellular environment, as well as whole micro-cells. mechanical modeling, to elucidate the multi-scale details of the transfer of mechanical stresses to nuclear constituents [3].
The objectives of this project are therefore twofold and parallel:
$ In the first part of the project, we will focus on observing and quantifying the mechanical link between extranuclear cellular structures and the nucleus;
$ In the second part, we will monitor chromatin reorganization and identify possible chromatin and DNA damage due to mechanical forces.
The main focus of this doctoral fellowship is the theory and modeling portion of the project (see below, prerequisites for applicants).
You can find more background information in the following references:
[1] Perret, G., et al., Microsys. Nanoeng. (Nature) 2, 16062, DOI : 10.1038/micronano.2016.62 (2016)
[2] Pékin, D., et al., IEEE 33rd Int. Conf. sur MEMS, 62-65, DOI : 10.1109/MEMS46641.2020.9056362 (2020)
[3] Cleri, F., Giordano, S., Blossey, R., J. Mol. Biol. 435, 168263, DOI: 10.1016/j.jmb.2023.168263 (2023)

Doctoral contract grant funded by the ANR project "DNASTRIX: DNA damage at nuclear constrictions".