IE-IR Research Engineer (M/F)

TN France; Paris; Sur place; EUR 35 000 - 55 000; Plein temps

Résumé du poste

An innovative research organization is seeking a talented engineer to contribute to groundbreaking projects in genome stability mechanisms. This role involves working closely with a dynamic team to explore DNA repair pathways and develop new therapeutic targets for cancer treatment. You'll engage in hands-on laboratory work, including cloning and protein purification, while collaborating with experts in the field. With a commitment to inclusivity and research integrity, this opportunity offers a chance to make a significant impact in cancer research and patient care. Join a forward-thinking team dedicated to advancing scientific knowledge and improving lives.

Prestations

Collective Catering

Transportation Reimbursement

Supplementary Health Insurance

Qualifications

• Master's degree in molecular biology or biochemistry required.
• Strong communication and organizational skills are necessary.

Responsabilités

• Elucidate molecular mechanisms of mitotic repair.
• Collaborate with PhD students and postdoctoral fellows.

Connaissances

Molecular Biology

Biochemistry

Protein Purification

Microscopy

Cloning

Protein-Protein Interaction Assays

Communication Skills

Organizational Skills

Formation

Master's Degree in Molecular Biology

Master's Degree in Biochemistry

Outils

Super-Resolution Microscopy

Description du poste

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Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital Group and a Research Center with more than 1000 employees, aiming to develop basic research and use this knowledge to improve cancer diagnosis, prognosis, and therapeutics, serving the continuum between research and innovation for patient benefit.

Laboratory

The DNA repair mechanisms in cancers research group (Ceccaldi Lab) is seeking an engineer (IE or IR) to drive cutting-edge research projects focused on understanding genome stability mechanisms.

Our team has made significant contributions to genome stability and tumor biology, focusing on compensatory mechanisms in cancer cells with defects in homologous recombination (HR)-mediated repair. We explore new mechanisms and pathways that control genome stability and HR-deficient tumor survival.

From a translational perspective, we have identified and developed inhibitors against new drug targets for breast and ovarian tumors, emphasizing the importance of studying DNA repair pathway interactions for therapeutic exploitation. Our long-term goals include discovering new regulators of genome stability, understanding DNA repair interconnections, and developing new drugs and biomarkers for targeted therapy.

Recent publications include:

1. Zhou, J. et al. A first-in-class Polymerase Theta Inhibitor targets HR-deficient tumors. Nature Cancer, 2021.
2. Gelot, C. et al. Polθ phosphorylation by PLK1 in mitotic double-strand break repair. Nature, 2023.
3. Kovacs, M. T. et al. DNA damage induces nuclear envelope rupture via ATR-mediated lamin A/C phosphorylation. Molecular Cell, 2023.
4. Musiani, D. et al. UNG inhibition triggers homologous recombination and kills BRCA1/2-deficient tumors. In revision, 2024.

Mission

The applicant will work on elucidating molecular mechanisms of mitotic repair, collaborating with a PhD student and a postdoctoral fellow. Tasks include:

• Cloning
• Protein purification (E. coli, insect cells)
• Protein-protein interaction assays
• Microscopy

Applicants should hold a master's degree in molecular biology or biochemistry. Additional expertise in biochemistry or super-resolution microscopy is preferred. Strong communication skills and organizational capacity are required. Fluency in professional English and/or French is necessary.

All opportunities are open to people with disabilities.

Contract Details

• Type: Fixed-term contract
• Start date: As soon as possible
• Duration: 3 years
• Work hours: Full-time, 39 hours/week
• Salary: According to current grids
• Benefits: Collective catering, transportation reimbursement up to 70%, supplementary health insurance

Location: Paris

Application: Please send your CV, a motivation letter, and contact details of at least two referees.

Publication date: 07 May 2024

Application deadline: 31 July 2024

Institut Curie is an inclusive, equal opportunity employer committed to research integrity.