IE-IR Research Engineer (M / F)

Institut Curie; Paris; Sur place; EUR 35 000 - 55 000; Plein temps

Résumé du poste

Une entreprise de recherche de premier plan cherche un ingénieur passionné pour rejoindre une équipe dynamique. Ce rôle implique de plonger dans des projets de recherche de pointe sur la stabilité du génome et les mécanismes de réparation de l'ADN. Vous aurez l'opportunité de travailler sur des projets innovants, en utilisant des techniques de clonage et de microscopie, tout en contribuant à des découvertes qui pourraient révolutionner le traitement des cancers. Si vous êtes motivé par la recherche et souhaitez faire une différence dans le domaine de la biologie du cancer, cette opportunité est faite pour vous.

Prestations

Restauration collective

Remboursement des frais de transport jusqu'à 70%

Assurance santé complémentaire

Qualifications

• Diplôme de master en biologie moléculaire ou biochimie requis.
• Expertise en biochemie ou microscopie de super-résolution souhaitée.

Responsabilités

• Travailler sur un projet de réparation mitotique des mécanismes moléculaires.
• Collaborer avec un doctorant et un postdoctorant.

Connaissances

Biologie moléculaire

Biochemie

Microscopie de super-résolution

Compétences en communication

Organisation

Formation

Master en biologie moléculaire ou biochimie

Outils

Clonage

Microscopie

Description du poste

Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital Group and a Research Center of more than 1000 employees with a strong international objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.

Laboratory

The research group DNA repair mechanisms in cancers (Ceccaldi Lab) is seeking an engineer (IE or IR) driving cutting-edge research projects aiming at understanding the mechanisms regulating genome stability.

In recent years, our team has made significant contributions to the field of genome stability and tumor biology. Focusing on compensatory mechanisms employed by cancer cells with defects in homologous recombination (HR)-mediated repair, we shed light on new mechanisms and pathways controlling genome stability and Homologous Recombination (HR)-deficient tumor survival.

From a translational point of view, our group has identified (and developed inhibitors against) new drug targets for the treatment of breast and ovarian tumors and highlighted the importance of studying the relationships between the different DNA repair pathways to better understand their interaction and exploit them for therapeutic purposes. Our long-term research goals hinge on the critical need for 1) new scientific approaches to discover additional regulators and effectors of genome stability, 2) basic understanding of interconnections between DNA repair processes, and 3) new drug development and biomarkers for anticancer targeted therapy.

Recent publications from the team

1. Zhou, J. et al. A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors. Nature Cancer, 2021.
2. Gelot, C. et al. Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis. Nature, 2023.
3. Kovacs, M. T. et al. DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A / C. Molecular Cell, 2023.
4. Musiani, D. et al. SMUG1 trapping at unprocessed uracil upon UNG inhibition triggers homologous recombination and selectively kills BRCA1 / 2-deficient tumors. In revision, 2024.

Missions

The applicant will work on a project aiming at deciphering the molecular mechanism(s) of mitotic repair. The applicant will work closely with a PhD student and a postdoctoral fellow and conduct experiments including:

• Cloning
• Microscopy

Prospective applicants should have a master's degree in molecular biology or biochemistry. The ideal applicant has further expertise in biochemistry or super-resolution microscopy. Great communication skills are needed, together with appropriate organizational capacity.

Professional English and/or French level required.

All our opportunities are open to people with disabilities.

Contract information

Type of contract: Fixed-term contract

Starting date: As soon as possible

Duration: 3 years

Working time: full time - 39 hours per week

Remuneration: according to the current grids

Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance

Location of the position: Paris

Contact

Please send your application including your CV, a letter of motivation explaining why you would like to join our team, and contact information of at least two referees.

Publication date: 07th of May 2024

Deadline for application: 31st of July 2024

Institut Curie is an inclusive, equal opportunity employer and is dedicated to the highest standards of research integrity.