Engineer or postdoctoral researcher in instrumentation for bioproduction H/F

CEA; Grenoble; Sur place; EUR 40 000 - 70 000; Plein temps

Résumé du poste

Une entreprise innovante recherche un ingénieur ou chercheur postdoctoral pour optimiser des instruments de bioproduction. Ce rôle implique la conception d'un instrument d'encapsulation pour des cellules humaines, en intégrant des fonctions de comptage et de transfert de microbilles. Le candidat collaborera avec des biologistes pour valider les développements techniques. Si vous êtes passionné par l'instrumentation et les technologies microfluidiques, et que vous souhaitez contribuer à des projets de pointe, cette opportunité est faite pour vous.

Qualifications

• Ph.D. ou diplôme d'ingénieur avec expérience en instrumentation.
• Compétences en conception de systèmes et technologies microfluidiques.

Responsabilités

• Optimiser un instrument d'encapsulation pour la bioproduction.
• Conception et validation d'un prototype fonctionnel.

Connaissances

Conception de systèmes

Technologies microfluidiques

Gestion de projet

Impression 3D

Utilisation de SolidWorks

Formation

Doctorat en instrumentation

Diplôme d'ingénieur (MSc)

Outils

SolidWorks

Systèmes optiques

Outils informatiques

Description du poste

Engineer or Postdoctoral Researcher in Instrumentation for Bioproduction H/F

Domaine

Contrat

CDD

Position Overview

The candidate will optimize an instrumentation and a microfluidic card for encapsulating human cells in monodisperse microbeads of extracellular matrix. Within a few days, cells encapsulated in microbeads form organoids or tumoroids, which are miniature 3D cellular models of biological tissues or tumors.
Based on the microfluidic instruments previously developed in the team, you will design and assemble an encapsulation instrument incorporating functions for automatic counting and transfer of microbeads to the appropriate medium for organoid and tumoroid culture. Your mission will be to adapt the team's previous work and develop a new high-throughput cell encapsulation instrument comprising a microfluidic card, a mechanical holder, pneumatic controllers, temperature control units, optical systems, and IT tools. These technical developments will be carried out and validated in collaboration with biologist users.

Required Work

1. Analysis of requirements and definition of technical specifications to meet them: scale-up + GMP production of organoids and tumoroids
2. Design of the optimized functional prototype
3. Incorporation of microbead counting and transfer functions
4. Validation and qualification of the bioproduction instrument
5. Design specifications of the pre-industrial prototype

Activities

1. Instrumentation / interfacing
2. Dimensioning of the components
3. CAD design (SolidWorks) of the instrument including fluid management, thermal management, imaging systems, and image processing module
4. Design and production of parts by 3D printing
5. Management of subcontracting: supply of components, machining
6. Parameterization of components
7. Assembly of the equipment
8. Functional validation of the developed equipment

Qualifications

- Holder of a Ph.D. or an engineering (MSc) degree with a focus on instrumentation.
- At least 2 years of professional experience with a first experience in similar functions.
- Good skills in system design in microfluidic technologies.
- Qualities: organization, rigor, dynamism, initiative, team spirit.

Site

Grenoble

Start Date

01/09/2025

Référence

2025-36008