Engineer IE in Molecular and Cell Biology (M / F)

Institut Curie; Paris; Sur place; EUR 35 000 - 55 000; Plein temps

Résumé du poste

An established industry player in cancer research is seeking a dedicated engineer to join their Molecular Mechanism of Chromosome Dynamics group. This exciting opportunity involves studying centromere aberrations in cancer using advanced interdisciplinary approaches. The successful candidate will engage in various activities, including cell culture, genome editing with CRISPR/Cas9, and employing cutting-edge microscopy techniques. This role promises to contribute significantly to innovative research aimed at improving cancer diagnostics and therapeutics. If you are passionate about making a difference in cancer research, this position offers a chance to work in a collaborative and inclusive environment.

Prestations

Collective Catering

Transportation Fee Reimbursement (up to 70%)

Supplementary Health Insurance

Qualifications

• Candidates must have an engineering or master's degree in biology.
• Previous expertise in microscopy and molecular biology is recommended.

Responsabilités

• Conduct cell culture, clone isolation, and treatment with compounds.
• Develop novel imaging approaches to detect chromosome translocations.

Connaissances

Microscopy

Molecular Biology

Cell Culture

Data Analysis

Genome Editing (CRISPR/Cas9)

Formation

Engineering Degree

Master's Degree in Biology

Outils

Digital Droplet PCR

Live Cell Imaging

Super Resolution Microscopy

Multicolor FISH

Description du poste

Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital group and a Research Center of more than 1000 employees with a strong international representativeness. The objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.

Laboratory

The engineer will work in the Molecular Mechanism of Chromosome Dynamics group headed by Daniele Fachinetti.

The project

The selected candidate will study the causes and consequences of centromere aberrations in cancer using interdisciplinary approaches in cell and cancer cell models. The selected candidate will work together with members of the Fachinetti group to elucidate the repair mechanisms acting at broken centromeres. One of the tasks will be to develop novel imaging approaches to detect chromosome translocations.

Activity description

• Cell culture, clone isolation and characterization, treatment with various compounds;
• Genome editing with CRISPR / Cas9 technology and lentivirus approaches;
• Microscopy techniques (live cell imaging, super resolution, multicolor FISH for karyotype analysis);
• Implementation of the digital droplet PCR for measuring repetitive elements;
• Development of expansion microscopy on metaphase chromosomes;
• Molecular biology assays (DNA, RNA and protein extraction-Implementing, cloning);
• Data analysis;
• Communication of results at meetings.

Training and Skills required

Candidates must hold an engineering degree or a master's degree in biology. Previous expertise in microscopy, in the usage of tissue culture models and molecular biology are recommended. Professional English level is required.

All our opportunities are open to people with disabilities.

Contract information

Type of contract : Fixed-term contract.

Starting date : From July / September.

Working time : full time.

Remuneration : according to the current grids.

Benefits : Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance.

Location of the position : Paris 5th (downtown).

Reference : NA.

Research funds are available thanks to a Research Center program at I. Curie and public generosity.

Contact

To apply, please send your CV and cover letter (2 pages maximum).

Deadline for application : 31st of August.

Institut Curie is an inclusive, equal opportunity employer and is dedicated to the highest standards of research integrity.