Doctoral (PhD) student position in mucosal vaccination

Équipe Immunité Innée et défenses pulmonaires anti-infectieuses (unité INSERM U1152); Les Ulis; Sur place; EUR 24 000 - 30 000; Plein temps

Résumé du poste

Un poste de doctorant de 3 ans est à pourvoir à l'unité INSERM de la School of Medicine à Paris. Le projet vise à développer des stratégies de vaccins intranasaux, impliquant la création de vecteurs protéiques et l'évaluation de l'immunogénicité dans des modèles murins. Les candidats doivent avoir un Master-2, avec un intérêt pour l'immunologie et la biologie cellulaire.

Prestations

Public funding support

Collaboration avec des instituts de recherche renommés

Qualifications

• Doit être titulaire d'un Master-2 ou équivalent.
• Expérience en immunologie ou biologie cellulaire souhaitée.
• Motivation à travailler dans un environnement académique multidisciplinaire.

Responsabilités

• Effectuer des expériences et reproduire des protocoles expérimentaux.
• Analyser les données expérimentales et tenir des archives de données.
• Collaborer avec d'autres membres du laboratoire et équipes de recherche.
• Présenter les données lors des réunions de laboratoire.

Connaissances

Immunologie

Biologie cellulaire épithéliale

Ingénierie/Chimie des protéines

Formation

Master-2 ou équivalent

Description du poste

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Job Reference:

d2d24736007c

Job Views:

3

Posted:

21.06.2025

Expiry Date:

05.08.2025

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Job Description:

A 3-year PhD position supported by the ANR program is available at the U INSERM unit, School of Medicine (site Bichat), Paris (Team: Innate immunity and anti-infective pulmonary defences, Professor JM Sallenave).

The PhD will be supervised by Dr Ignacio GARCIA-VERDUGO. The host laboratory investigates host-pathogen interactions and develops new therapies to enhance mucosal immunity in the context of lung infections

Project .

The goal of this project is to develop new intranasal vaccines strategies. Specifically, this project aims to develop protein vectors for intranasal delivery of vaccine antigens. The project integrates protein engineering and mucosal immunology. Specifically, the project aims: 1) To construct specific vaccine protein vectors and to evaluate the interaction of the constructs with the respiratory-associated immune system vitro. 2) To evaluate in vivo the immunogenicity and efficiency of intranasal vaccine formulations in a murine model of influenza virus infection. The project will be performed in collaboration with other research teams at Pasteur Institute and Cochin Institute in Paris.

Candidate Profile .

We are looking for highly motivated individuals willing to work in a multi-disciplinary academic environment.

Candidates must have a Master-2 degree or equivalent level to apply (French Bac). In addition, the candidate is expected to have a scientific background in at least one of the following fields: immunology, epithelial cell biology, protein engineering/chemistry. Any additional specific technological/scientific expertise will be valued as an asset.

Missions
The candidate is expected to:
1. Perform experiments and reproduce experimental protocols using in vitro and in vivo (animal experimentation) approaches.

2. Analyse experimental data and keep organized data archives.
3. Interact and collaborate productively with other lab members and research teams.
4. Present data in lab meetings and communicate research outputs in international scientific meetings.

Contact & applications . For applications, please send to Mr Garcia-Verdugo one CV (including recent academic grades), a motivation letter and the email contact for 2 references.

Funding category

Public funding alone (i.e. government, region, European, international organization research grant)

Topic description

A 3-year PhD position supported by the ANR program is available at the U INSERM unit, School of Medicine (site Bichat), Paris (Team: Innate immunity and anti-infective pulmonary defences, Professor JM Sallenave).

The PhD will be supervised by Dr Ignacio GARCIA-VERDUGO. The host laboratory investigates host-pathogen interactions and develops new therapies to enhance mucosal immunity in the context of lung infections

Project .

The goal of this project is to develop new intranasal vaccines strategies. Specifically, this project aims to develop protein vectors for intranasal delivery of vaccine antigens. The project integrates protein engineering and mucosal immunology. Specifically, the project aims: 1) To construct specific vaccine protein vectors and to evaluate the interaction of the constructs with the respiratory-associated immune system vitro. 2) To evaluate in vivo the immunogenicity and efficiency of intranasal vaccine formulations in a murine model of influenza virus infection. The project will be performed in collaboration with other research teams at Pasteur Institute and Cochin Institute in Paris.

Candidate Profile .

We are looking for highly motivated individuals willing to work in a multi-disciplinary academic environment.

Candidates must have a Master-2 degree or equivalent level to apply (French Bac). In addition, the candidate is expected to have a scientific background in at least one of the following fields: immunology, epithelial cell biology, protein engineering/chemistry. Any additional specific technological/scientific expertise will be valued as an asset.

Missions
The candidate is expected to:
1. Perform experiments and reproduce experimental protocols using in vitro and in vivo (animal experimentation) approaches.

2. Analyse experimental data and keep organized data archives.
3. Interact and collaborate productively with other lab members and research teams.
4. Present data in lab meetings and communicate research outputs in international scientific meetings.

Contact & applications . For applications, please send to Mr Garcia-Verdugo one CV (including recent academic grades), a motivation letter and the email contact for 2 references.

Funding category

Public funding alone (i.e. government, region, European, international organization research grant)

Funding further details

ANR