CDD chercheur M/F Interactions microalgues-bactéries, expérimentation biologique et bioinformatique

CNRS; France; On-site; EUR 32,000 - 45,000; Full time

Job summary

CNRS in France seeks a First Stage Researcher to design and conduct experiments characterizing microalgae–bacteria interactions, including co-culture systems, under sterile conditions.

Responsibilities include generating and analyzing molecular, biochemical and physiological data, performing high-throughput RNA-seq analyses, and contributing to publications, with emphasis on data integration and epigenomic responses.

Qualifications

• Proficiency in culturing bacteria and microalgae under sterile conditions.
• Strong molecular biology skills including DNA/RNA extraction, PCR/qPCR, cloning and mutagenesis.
• Experience in protein and metabolite extraction/analysis and microscopy.
• Experience with physiological experiments and growth monitoring.
• Bioinformatics experience with high-throughput sequencing (RNA-seq) and multi-omics data.
• Ability to integrate diverse datasets and perform data-driven interpretation.
• Programming in R/Python (Linux) for data analysis and visualization.
• Excellent oral and written scientific communication in English.

Responsibilities

• Design and conduct experiments to characterize microalgae–bacteria interactions.
• Set up microbial and algal physiology experiments under controlled conditions.
• Generate and analyze molecular, biochemical and physiological data.
• Characterize molecular/metabolic mechanisms in microalgae–bacteria systems.
• Generate, process and integrate multi-omics datasets.
• Contribute to data interpretation, dissemination and publications.
• Ensure traceability and documentation of experimental data and protocols.
• Perform sterile cultures, DNA/RNA/protein/metabolite extractions.
• Perform PCR, qPCR, cloning, mutagenesis and transformation.
• Carry out high-throughput bioinformatics analyses (RNA-seq, assembly, metadata).
• Work with Leïla Tirichine and team on epigenomics research.

Skills

Sterile culturing

Molecular biology

DNA/RNA extraction

PCR/qPCR

Cloning and mutagenesis

Protein/metabolite analysis

Microscopy

Physiological assays

Bioinformatics (RNA-seq)

Multi-omics integration

R, Python, Linux

Education

Doctoral research exposure or equivalent

Tools

R

Python

Linux

RNA-seq analysis tools

Job description

Organisation/Company CNRS Department Unité en Sciences Biologiques et Biotechnologies Research Field Biological sciences Technology » Biotechnology Researcher Profile First Stage Researcher (R1) Application Deadline 29 Oct 2026 - 23:59 (UTC) Country France Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 18 Jan 2027 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Design and conduct experiments aimed at characterizing microalgae–bacteria interactions, using both individual cultures and co-culture systems.

Set up and monitor microbial and algal physiology experiments under controlled conditions.

Generate and analyse molecular, biochemical and physiological data to characterize microbial responses to different experimental conditions.

Contribute to the characterization of the molecular and metabolic mechanisms underlying microalgae–bacteria interactions.

Generate, process and integrate multi-omics datasets to identify biological mechanisms and functional responses of the microorganisms under study.

Contribute to the integrated interpretation of experimental results, the scientific dissemination of the work, and the preparation of scientific publications and presentations.
Ensure the traceability, organization and documentation of experimental data and protocols.

Perform sterile cultures of bacteria and microalgae, both separately and in co-culture.

Extract DNA, RNA, proteins and metabolites.

Perform PCR, qPCR, Western blotting and microscopy.

Conduct microbial and algal physiology experiments.

Perform cloning, mutagenesis and transformation.
Conduct high-throughput bioinformatics analyses, including RNA-seq, sequence assembly, metadata analysis, metabolomics and multi-omics data integration.

The position is based within the “Microalgal Epigenomics and Interactions with the Environment” team at the US2B laboratory (UMR 6286). The team investigates the molecular, and particularly epigenetic, responses of microalgae to their environment, including both biotic factors (bacteria) and abiotic factors (salinity, temperature, nutrient limitation and photo-oxidative stress).
The successful candidate will work primarily with Leïla Tirichine.

Experimental skills
Proficiency in culturing bacteria and microalgae under sterile and controlled conditions.
Proficiency in molecular biology techniques, including DNA and RNA extraction, PCR/qPCR, cloning, mutagenesis and transformation.
Experience in protein and metabolite extraction and analysis.
Good experience with microscopy techniques.
Experience in physiological experiments and in monitoring growth parameters and cellular responses.
Bioinformatics skills
Proficiency in the analysis of high-throughput sequencing data, particularly RNA-seq.
Experience in genome and/or metagenome assembly and analysis.
Experience in the analysis and integration of multi-omics data, particularly transcriptomic and metabolomic datasets.
Ability to process, analyse and interpret high-throughput biological datasets.
Proficiency in one or more programming and data analysis environments/tools (R, Python, Linux, etc.).
Ability to integrate experimental datasets of different types and establish links between molecular, physiological and metabolic data.
Transferable skills
Ability to independently plan and organize experiments.
Rigorous approach to experimental work, data documentation and analysis.
Ability to interpret complex results and formulate scientific hypotheses.
Ability to work effectively as part of a team and interact with researchers from different disciplines.
Strong scientific communication skills in English, both written and oral.
Ability to disseminate and valorise research findings through reports, presentations and scientific publications.

Additional comments