Gérant de Bar H / F

KEOLIS, WOLKSWAGEN ROLLAND, CHATEAUX GDM, CITROEN, PEUGEOT DELANAUX, RENAULT FURGALA; Reims; Sur place; EUR 20 000 - 40 000; Plein temps

Résumé du poste

An innovative opportunity awaits a Ph.D. candidate in a groundbreaking project focused on the sustainable production of 4-vinyl phenols. This research role involves developing a millifluidic reactor through a unique droplet-based approach, aiming to optimize the enzymatic conversion of p-hydroxycinnamic acids into valuable products. You will work closely with a consortium of esteemed partners, employing both experimental and numerical methods to enhance production efficiency. Join a forward-thinking team dedicated to advancing biotechnology and contributing to sustainable practices in the chemical industry. This is your chance to make a significant impact in a rapidly evolving field.

Qualifications

• Experience with enzymatic processes and reactor design.
• Strong background in numerical simulations and fluorescence detection.

Responsabilités

• Develop a millifluidic reactor using a droplet-based experimental approach.
• Collaborate with project partners for scaled-up reactor implementation.

Connaissances

Enzymatic tools

Biomass production

Numerical simulations

Fluorescence detection

Formation

Ph.D. in Biotechnology or related field

Outils

Millifluidic reactor

Multiphasic flow simulation software

Description du poste

The increasing customer demand for natural antioxidants and flavors aligns with the emergence of new enzymatic tools that offer alternative ways to access healthier flavor compounds. Styrenes, such as 4-vinyl phenols, are particularly valuable products in the food, cosmetic, pharmaceutical, and chemical industries. Typically, they are obtained through the chemical decarboxylation of p-coumaric acid (p-CA) or ferulic acid (FA), which are p-hydroxycinnamic acids (p-HCAs), using metal catalysts under harsh conditions. However, this raises concerns about product safety and the generation of hazardous waste. Consequently, there is a growing research focus on the sustainable production of renewable 4-vinyl phenol from biomass. The MilliStyrene project, funded by the ANR (Agence National de la Recherche), involves a consortium consisting of URD ABI from AgroParisTech, CRPP (Centre de Recherche Paul Pascal) located in Bordeaux, and the Chair of Biotechnology of CentraleSupélec. This project represents the initial endeavor to substantially decrease the cost of biobased 4-vinyl phenols by developing an innovative In-Stream Product Recovery (ISPR) compartmentalized millifluidic reactor for the enzymatic conversion of p-HCAs into 4-vinyl phenols.

As part of the MilliStyrene project, this Ph.D. thesis aims to develop a millifluidic reactor using a droplet-based experimental approach. The objective is to define potential reactor design (shape, size, flow rates, indexes length…), and to realize and test one or two candidate designs. This requires the development of a detection method for both p-HCAs and 4-vinyl phenols through their natural fluorescence, along with a numerical approach based on multiphase flow simulations coupled with products diffusion and reaction rates. The combination of experimental and numerical works will be utilized for testing and optimizing the miniaturized production. Lastly, based on the computational tools and the results gained by the candidate designs, the Ph.D. candidate will collaborate with the project partners to implement a scaled-up continuous millifluidic reactor.

Funding category: Other public funding

The Ph.D. thesis is funded by ANR (Agence National de la Recherche) and the chair of Biotechnology.