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Une opportunité passionnante s'offre à vous dans le cadre d'un projet de recherche innovant sur les biomatériaux à base de titane. Ce projet vise à développer des traitements de surface pour améliorer les implants médicaux, en mettant l'accent sur la réponse biologique et les propriétés mécaniques. Vous aurez l'occasion de travailler au sein de laboratoires de pointe, en utilisant des techniques de caractérisation avancées pour répondre aux exigences des cliniciens. Si vous êtes passionné par la recherche et souhaitez contribuer à des avancées significatives dans le domaine médical, cette thèse est faite pour vous.
Organisation/Company: Université Polytechnique Hauts de France
Research Field: Engineering » Electronic engineering
Researcher Profile: Recognised Researcher (R2), Leading Researcher (R4), First Stage Researcher (R1), Established Researcher (R3)
Country: France
Application Deadline: 30 Dec 2025 - 22:00 (UTC)
Type of Contract: Temporary
Job Status: Full-time
Is the job funded through the EU Research Framework Programme? Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure? No
This thesis is part of the European SAFE project, which focuses on titanium (Ti)-based biomaterials used in the manufacture of medical implants, particularly those used in orthopedic surgery (screws, plates, endoscopes, etc.), vascular surgery (stents, etc.) and dental implantology (screws, abutments, etc.). They are used to replace lost or diseased biological structures, restore function or shape. Ti implants are widely used in the dental field, where they are confronted with real clinical problems linked to the slow biological response to their surface, slow osseointegration and bacterial colonization leading to loosening of the implant and consequent loss of viability. The performance requirements for implants are good mechanical properties, controlled resistance to corrosion in biological environments, antibacterial properties and adequate biological response. Surface modifications are therefore necessary to optimize their functional properties. In this context, the SAFE project's innovation is the development and combination of plasma and dry surface treatment technologies to microstructure and nanostructure the surface (in Ti) to meet the demanding specifications of clinicians and hospitals, and to innovate in the development of biomaterials. The proposed combination of plasma technologies has not yet been envisaged in other projects, and offers the prospect of a TRL rise from 3 to 7 for Titanium dental implants and an endoscopic device.
Two UPHF laboratories will be involved in co-directing this thesis: IEMN (Valenciennes site) and LAMIH. These two laboratories will contribute their expertise, notably in surface characterization using ultrasound (IEMN) and indentation (LAMIH). This multi-disciplinary approach will be put to good use, both in terms of mechanical and morphological characterization of surfaces, and in assessing their biological properties.
Mechanical characterization at the UPHF will be carried out in a multiphysics context, notably using non-destructive methods based on ultrasound using surface acoustic waves. This work will be carried out on a WAVESURF platform at the IEMN Valenciennes site. On the other hand, LAMIH will contribute its experience in the mechanical characterization of surfaces using instrumented indentation techniques (MORPHOOMECA platform). The strength of this co-direction will lie in its multi-scale instrument park and in the skills developed around these techniques with the characterization of metallic or ceramic materials in solid, coated, multiphase or porous form.
As part of this thesis, we will be proposing the optimization of surface functionalization parameters in line with the project's objectives. To evaluate antibacterial treatments on pathogenic bacteria, an inter-comparison will be made between the ultrasonic and indentation techniques, the mechanisms and directions of material stress being different. For ultrasound, the technique will be refined (development of SAW transducers) to achieve sufficiently high excitation frequencies to probe thinner and thinner layers. For indentation tests, a wide range of loadings will be applied, enabling the study of local behavior right through to the behavior of the mass. These tests can also be carried out in an environment that simulates the end-use environment. The indicators extracted will be Young's modulus, Poisson's ratio, hardness, toughness, etc., depending on the intended end application. Mapping of mechanical properties can be proposed and compared with other characteristics such as morphology and corrosion.
Début de la thèse: 01/10/2025
Number of offers available: 1
Company/Institute: Université Polytechnique Hauts de France
Country: France
City: Villeneuve d'Ascq