Bioinformaticien

SFBI; Mérignac; Sur place; EUR 40 000 - 70 000; Plein temps

Résumé du poste

Ein innovatives Forschungsteam sucht einen Bioinformatiker, der sich auf die Analyse von Omics-Daten spezialisiert hat. In dieser spannenden Rolle werden Sie an der Entwicklung von Organoid-Modellen für pädiatrische Krebserkrankungen arbeiten und Mechanismen des Therapie-Widerstands untersuchen. Sie werden eng mit Biologen und anderen Bioinformatikern zusammenarbeiten, um Daten zu verarbeiten und Analyse-Pipelines zu entwickeln. Diese Position bietet die Möglichkeit, einen bedeutenden Beitrag zur Krebsforschung zu leisten und Ihre Fähigkeiten in einem dynamischen Umfeld weiterzuentwickeln.

Qualifications

• Erfahrung in der Analyse von Next Generation Sequencing-Daten.
• Gute Kenntnisse in Statistik und Programmierung sind erforderlich.

Responsabilités

• Verarbeitung und Analyse von multi-skaligen Omics-Daten.
• Entwicklung und Wartung von Analyse-Pipelines im Team.

Connaissances

Bioinformatik

Statistik

Programmierung (R, Linux/Bash, Python oder Perl)

Nächste Generation Sequenzierung

Pipeline-Entwicklung (Snakemake, Nextflow)

Formation

Ingenieurabschluss, M2 oder PhD in Bioinformatik

Outils

Snakemake

Nextflow

Git

Description du poste

Pediatric Cancers, Next Generation Sequencing, Omics data analysis, Organoids

Description

The establishment of cancer-derived organoids has recently begun to emerge as a prominent and promising tool to enhance our understanding of human cancers (Broutier et al., nature protocols 2016 & Broutier et al., nature medicine 2017). However, such models have as yet not been developed for pediatric cancers. The research program that we develop in the C3 lab forms part of this perspective with the objective to elaborate innovative organoid models to address pediatric cancers specificities and complexity, with a special focus on the mechanisms of resistance to treatments. We are affiliated to the Cancer Research Centre of Lyon (CRCL –INSERM U1052 / CNRS 5286) and to the Centre Léon Bérard’s Pediatric hospital (IHOPE). Our group is therefore composed of researchers (biologists & bioinformaticians), clinicians and pathologists.

The candidate will work with other bioinformaticians and biology researchers. In brief, the candidate will be responsible for processing and analyzing multi-scale omics data: targeted-DNAseq, RNA-seq (bulk and single cell (10X)), MethylEPIC 850K, and proteomics. The main focus of the candidate will be to explore, by using these datasets, mechanisms of resistance to treatment in pediatric gliomas and rhabdomyosarcomas. The key players identified by the candidate will be validated in the lab on organoid models. To ensure reproducibility, analysis pipelines are being developed in the team. The candidate is expected to help maintain and develop these pipelines.

Salary:
Salary will follow the rules of the Cancer Research Center of Lyon (CRCL) and will depend on the experience of the candidates.

Candidate profile:

1. Holder of an engineering degree, M2, PhD in bioinformatics with a specialization in biostatistics
2. Working experience in Next Generation Sequencing/Illumina technology analyses
3. A good knowledge in statistics and in programming (R, linux/bash, python or perl)
4. Knowledge in tools for pipeline development (snakemake, Nextflow) and versioning (git)
5. Basic knowledge in cancer biology and genetics

Candidature

Procédure : Interested candidates should send a short curriculum vitae with a description of previous training & work experiences + a motivation letter to [e-mail]. Please specify "BIOINFO_APPLICATION_" followed by your name in the subject line.

Contacts