Bioinformatician engineer (M/F)

European Commission; France; Sur place; EUR 40 000 - 60 000; Plein temps

Résumé du poste

A leading research center in France seeks a Bioinformatics Engineer to analyze genomic data related to cancer research. The role involves collaborating with biologists to uncover molecular mechanisms of chromosome dynamics, requiring expertise in bioinformatics and programming. Candidates should possess strong analytical and communication skills, with a focus on high-throughput sequencing analysis.

Prestations

Collective Catering

Transportation Fee Reimbursement up to 70%

Supplementary Health Insurance

Qualifications

• Master’s or PhD in bioinformatics or biology with bioinformatics experience.
• Proficiency in Bash, R, Python, and experience with sequencing analysis.
• Strong writing, communication, and organizational skills.

Responsabilités

• Analyze high-throughput sequencing and genome-wide datasets.
• Work closely with experimental biologists on omics data.
• Focus on centromere dynamics and genome stability in cancer.

Connaissances

Bash

R

Python

Interpersonal Communication

Teamwork

Organizational Skills

Problem Solving

Self-Learning

Time Management

Fluency in English

Formation

Master’s or PhD in Bioinformatics

Experience in Biology with Bioinformatics

Outils

High-Performance Computing

Long-Read Sequencing Analysis

Short-Read Whole-Genome Sequencing

Transcriptomic Analysis

Description du poste

Organisation/Company Institut Curie - Research Center Department Administration Research Field Medical sciences » Cancer research Researcher Profile Recognised Researcher (R2) Positions PhD Positions Country France Application Deadline 30 Jul 2025 - 12:34 (Europe/Paris) Type of Contract Temporary Job Status Full-time Hours Per Week 39 Offer Starting Date 15 Aug 2025 Is the job funded through the EU Research Framework Programme? Horizon 2020 Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Hosting Institution

The Institut Curie, a key player in the fight against cancer, combines a hospital and a research center with over 1,000 staff members. The objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.

Description of the position

Laboratory

The engineer will work in the Molecular Mechanism of Chromosome Dynamics group headed by Daniele Fachinetti ( https://institut-curie.org/team/fachinetti ) focusing oncentromere dynamics and their role in genome instability.

The bioinformatics engineer will contribute to uncovering the molecular mechanisms regulating centromere identity, maintenance, and function, including their role in chromosome mis(segregation), aneuploidy, chromothripsis in cancer, through the analysis of high-throughput sequencing and genome-wide datasets. This position involves integrative analysis of WGS, scWGS, RNA-seq, scRNA-seq, Nanopore, and PacBio data to identify genetic and epigenetic factors that influence chromosome inheritance and genome stability.

A central focus will be the analysis of centromeres in the context of genome instability during development and cancer progression, including i) the role of centromere dynamics and aneuploidy in neuroblastoma onset and ii) how chromothripsis contributes to centromere dysfunction driving tumorigenesis.

The engineer will work closely with experimental biologists to analyse omics data related to cell cycle progression, replication timing, and chromatin architecture, supporting a multidisciplinary approach to understanding genome maintenance and instability.

Qualifications & Experience (recommended)

•Master’s or PhD in bioinformatics, or in biology with experience in bioinformatics

• Proficiency in Bash, R, and Python

• Familiarity with high-performance computing (HPC) environments

• Experience with long-read sequencing analysis

• Experience with short-read whole-genome sequencing

• Experience with transcriptomic analysis, including scRNAseq

• Good interpersonal communication, teamwork, and organizational skills

• Ability to self-learn and apply a problem-solving approach to work

• Strong writing and documentation skills

• Flexibility and time management skills to handle multiple projects in parallel

• Fluency in English (written and spoken)

Preference will be given to candidates with experience in long-read sequencing analysis.

Additional Information

• Location: work location at Institut Curie, rue d’Ulm, 75005 Paris.
• Contract: 18 months, possible extendible up to 3 years (COD).
• Start date: as soon as possible.
• Working time: full time.
• Remuneration: according to the current grids.
• Benefits: collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance

How to Apply

Interested candidates should send their CV, cover letter, and contact information for references to

The Institut Curie is an inclusive and equal opportunity employer and upholds strict standards in research integrity.

Institut Curie is an inclusive, equal opportunity employer and is dedicated to the highest standards of research integrity.