biochemistry researcher (M/F)

European Commission; France; Sur place; EUR 30 000 - 45 000; Plein temps

Résumé du poste

Une opportunité de post-doctorat au sein d'une unité de recherche reconnue dans le domaine de la glycobiologie, axée sur l'analyse des glycans et le développement de traitements pour les maladies congénitales liées à la glycosylation. Le candidat travaillera au sein d'une équipe dynamique, supervisant des stagiaires et participant à des projets internationaux, tout en développant des compétences techniques en biologie cellulaire et en biochimie.

Qualifications

• Connaissances générales en biologie et biologie cellulaire.
• Compétences en biologie cellulaire requises.
• Capacité à analyser et à présenter l'information.

Responsabilités

• Techniques de biologie cellulaire, analyse des glycans.
• Supervision des stagiaires de Licence et Master.
• Participation aux réunions internationales.

Connaissances

Biologie cellulaire

Glycobiologie

Anglais scientifique

Analyse

Rédaction scientifique

Formation

Formation en biologie ou domaine connexe

Outils

Western-blot

Lectin-blot

Description du poste

Organisation/Company CNRS Department Unité de Glycobiologie Structurale et Fonctionnelle Research Field Chemistry » Biochemistry Physics » Biophysics Biological sciences » Biological engineering Researcher Profile First Stage Researcher (R1) Country France Application Deadline 14 Jul 2025 - 23:59 (UTC) Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Oct 2025 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

As part of the ANR-DFG TreatProCDG project, the post-doctoral student in glycosciences will work on the analysis of glycans, the cellular environment, golgian trafficking and pH. The international project focuses on the role played by TMEM165 in the regulation of Ca/Mn ion homeostasis and golgi pH via potential interactions with the V-ATPase complex. The aim is to develop a treatment for CDG patients suffering from golgian pH deficiency using manganese supplementation.

I-Specific and principal activities - Cell biology techniques: Conservation and maintenance of fibroblast cell lines from CDG patients, stable and transient transfections, confocal microscopy and fluorescence analyses of the glycoproteome, imaging of living organisms. - Analysis of glycans and glycoproteins using classical glycomics approaches (mass spectrometry), metabolic labelling using non-natural sugar precursors and click chemistry (SiaNAl) and biochemistry (Western-blot and lectin-blot). - Development of a treatment for congenital glycosylation diseases linked to proton transport by manganese supplementation. II - Associated activities - Supervision of trainees (Bachelor's and Master's degrees) - Participation in international meetings - Funding applications

The Structural and Functional Glycobiology Unit is a multi-disciplinary research unit of around 150 people with an international reputation, where the research carried out is centred around a unifying theme: glycobiology. The studies carried out aim to understand the structure-function relationships of glycoconjugates. The person recruited will work in the 'Molecular mechanisms of glycosylation in health and diseases' team led by Dr François Foulquier. This team is interested in the structure-function relationships of glycoconjugates in healthy and pathological situations of genetic diseases of glycosylation (GCD). The young researcher's work will take place in building C9, on the campus of the University of Lille's Faculty of Science and Technology, avenue Mendeleïev in Villeneuve d'Ascq.

Research Field Biological sciences » Biological engineering Years of Research Experience None

Additional Information

Eligibility criteria

- Knowledge General knowledge of biology and mastery of the basics of cell biology. Knowledge of glycobiology would be appreciated. II- Skills Cell biology skills required. Technical skills in biochemistry (Western-blot and lectin-blot) and a good knowledge of glycobiology would be an advantage. Fluency in scientific English (reading and writing). Ability to analyse and present information. Drafting articles for publication in international peer-reviewed journals and literature reviews. III-Abilities (Personal skills) Motivation, diligence, dynamism, innovation and rigour Scientific curiosity, reliability in the execution of work and creativity Ability to work both independently and in collaboration within a research