Apprentice in Micellar Chemistry

Evotec WD; Toulouse; Sur place; EUR 20 000 - 40 000; Plein temps

Résumé du poste

Evotec, une organisation de R&D de premier plan, recherche un Apprenti en Chimie Micellaire à Toulouse. L'apprentissage se concentre sur le développement de solutions durables en chimie, intégrant des techniques avancées avec un soutien sur des projets innovants. Ce rôle s'adresse à des candidats passionnés par la chimie organique et les solutions écologiques.

Qualifications

• Doit être inscrit(e) dans un programme de bachelor, master ou ingénieur incluant un apprentissage.
• Intérêt marqué pour la chimie verte et la recherche.
• Expérience et connaissance des techniques de caractérisation.

Responsabilités

• Développer la chimie micellaire avec des surfactants spécifiques.
• Travailler sur des réactions comme les couplages pallado-catalysés.
• Démontrer autonomie et initiatives dans le cadre de projets de recherche.

Connaissances

Chimie organique

Chimie verte

Techniques de caractérisation

Autonomie

Initiative

Formation

Programme bachelor's ou master's en chimie

Diplôme d'ingénieur

Outils

LCMS

TLC

RMN

Description du poste

Apprentice in Micellar Chemistry page is loaded

Apprentice in Micellar Chemistry

Apply locations Toulouse time type Full time posted on Posted 2 Days Ago job requisition id JOB ID-12585

Context & apprenticeship subject: At Evotec – a world leading R&D partnering organization – we are committed to reduce the environmental impact of our activities, by adopting the green chemistry principles (1). We design chemical products and processes that reduce or eliminate the use or generation of hazardous substances. Green chemistry applies across the life cycle of a chemical product (from design to disposal). Guided by this principle, we recently developed a new working group specialized in micellar chemistry. The goal is to replace commonly used CMR solvents (DCM, DMF, dioxane, toluene etc…) by water. However, the use of water as the only solvent can be complicated, mainly due to the solubility of organic reagents. This is the reason why, in the early 2000’s, some research groups have developed surfactants for organic chemistry (2), enabling reactions to be carried out in water inside these micelles, the so called micellar chemistry.

The aim of this apprenticeship is to further develop micellar chemistry at Evotec. To achieve this, the student would have 3 surfactants at his/her disposal: TPGS-750-M, HPMC and SPGS-550-M also known as Nok (3). Those surfactants will be widely used for different types of reactions such as pallado-catalyzed cross couplings, reductions, amide couplings etc…

(1) Anastas, P. T.; Warner, J. C. Green Chemistry: Theory and Practice, Oxford University Press: New York,1998, 30, By permission of Oxford University Press

(2) a) Hedouin G., Ogulu D., Kaur G., Handa J., Chem. Commun., 2023,59, 2842 b) Lipshutz B.H., Gallou F., Handa S. ACS Sustainable Chem Eng. 2016, 4, 5838

(3) a) Fox R., Bailey J. D., Obligacion J. V., et al. Org. Process Res. Dev.2024, 28, 4, 978 b) Borlinghaus N., Wittmann V., Braje W. M., Current Opinion in Green and Sustainable Chemistry 2022, 33, 100571 c) Klumphu P. and Lipshutz B. H. J. Org. Chem. 2014, 79, 888

Candidate profile: The candidate must be enrolled in a professional bachelor's, master's, or engineering program that includes a work-study (apprenticeship) component., and possess solid skills in organic chemistry. The candidate is expected to demonstrate a keen interest in green chemistry and in developing more sustainable solutions. He/she should be familiar with classical characterization techniques (LCMS, TLC, NMR...), have a strong interest in research, innovation and demonstrate autonomy and initiatives.

FR : Dans le cadre de sa politique Diversité, Evotec étudie, à compétences égales, toutes les candidatures dont celles des personnes en situation de handicap.

ENG : In the frame of our Diversity policy, Evotec considers, with equal competences, all applications including people with disabilities.

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Evotec is a life science company with a unique business model that delivers on its mission to discover and develop highly effective therapeutics and make them available to the patients. The Company’s multimodality platform comprises a unique combination of innovative technologies, data and science for the discovery, development, and production of first-in-class and best-in-class pharmaceutical products. Evotec leverages this “Data-driven R&D Autobahn to Cures” for proprietary projects and within a network of partners including all Top 20 Pharma and over 800 biotechnology companies, academic institutions, as well as other healthcare stakeholders. Evotec has strategic activities in a broad range of currently underserved therapeutic areas, including e.g. neurology, oncology, as well as metabolic and infectious diseases. Within these areas of expertise, Evotec aims to create the world-leading co-owned pipeline for innovative therapeutics and has to-date established a portfolio of more than 200 proprietary and co-owned R&D projects from early discovery to clinical development. Evotec operates globally with more than 5,000 highly qualified people. The Company’s 17 sites offer highly synergistic technologies and services and operate as complementary clusters of excellence. For additional information please go to www.evotec.com and follow us on X/Twitter @Evotec and LinkedIn .

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