Apprentice in Micellar Chemistry

Evotec; Toulouse; Sur place; EUR 20 000 - 40 000; Plein temps

Résumé du poste

Evotec, un leader mondial en R&D, propose un stage en chimie organique axé sur la chimie micellaire. L'étudiant(e) participera au développement de méthodes durables, exploitant des surfactants pour réduire les solvants nocifs. Ce stage est destiné aux candidats motivés par l'innovation et soucieux de l'impact environnemental.

Qualifications

• Étudiant(e) en chimie avec un intérêt marqué pour la chimie verte.
• Compétences solides en chimie organique requises.
• Doit démontrer autonomie et initiative dans la recherche.

Responsabilités

• Développer la chimie micellaire pour remplacer des solvants CMR.
• Utiliser des surfactants pour réaliser diverses réactions chimiques.
• Contribuer à des solutions chimiques plus durables.

Connaissances

Chimie organique

Techniques de caractérisation (LCMS, TLC, NMR)

Autonomie

Initiative

Intérêt pour la chimie verte

Formation

Baccalauréat professionnel, Master ou diplôme d'ingénieur

Description du poste

Context & apprenticeship subject: At Evotec – a world leading R&D partnering organization – we are committed to reduce the environmental impact of our activities, by adopting the green chemistry principles (1). We design chemical products and processes that reduce or eliminate the use or generation of hazardous substances. Green chemistry applies across the life cycle of a chemical product (from design to disposal). Guided by this principle, we recently developed a new working group specialized in micellar chemistry. The goal is to replace commonly used CMR solvents (DCM, DMF, dioxane, toluene etc…) by water. However, the use of water as the only solvent can be complicated, mainly due to the solubility of organic reagents. This is the reason why, in the early 2000’s, some research groups have developed surfactants for organic chemistry (2), enabling reactions to be carried out in water inside these micelles, the so called micellar chemistry.

The aim of this apprenticeship is to further develop micellar chemistry at Evotec. To achieve this, the student would have 3 surfactants at his/her disposal: TPGS-750-M, HPMC and SPGS-550-M also known as Nok (3). Those surfactants will be widely used for different types of reactions such as pallado-catalyzed cross couplings, reductions, amide couplings etc…

(1) Anastas, P. T.; Warner, J. C. Green Chemistry: Theory and Practice, Oxford University Press: New York,1998, 30, By permission of Oxford University Press

(2) a) Hedouin G., Ogulu D., Kaur G., Handa J., Chem. Commun., 2023,59, 2842 b) Lipshutz B.H., Gallou F., Handa S. ACS Sustainable Chem Eng. 2016, 4, 5838

(3) a) Fox R., Bailey J. D., Obligacion J. V., et al. Org. Process Res. Dev.2024, 28, 4, 978 b) Borlinghaus N., Wittmann V., Braje W. M., Current Opinion in Green and Sustainable Chemistry 2022, 33, 100571 c) Klumphu P. and Lipshutz B. H. J. Org. Chem. 2014, 79, 888

Candidate profile: The candidate must be enrolled in a professional bachelor's, master's, or engineering program that includes a work-study (apprenticeship) component., and possess solid skills in organic chemistry. The candidate is expected to demonstrate a keen interest in green chemistry and in developing more sustainable solutions. He/she should be familiar with classical characterization techniques (LCMS, TLC, NMR...), have a strong interest in research, innovation and demonstrate autonomy and initiatives.

FR : Dans le cadre de sa politique Diversité, Evotec étudie, à compétences égales, toutes les candidatures dont celles des personnes en situation de handicap.

ENG : In the frame of our Diversity policy, Evotec considers, with equal competences, all applications including people with disabilities.