Protein Mass Spectrometry Scientist - Drug Discovery

Orion Corporation; Espoo; On-site; EUR 60,000 - 90,000; Full time

Job summary

Orion Corporation is seeking a curious and collaborative scientist with expertise in protein mass spectrometry to join the Structural Biology and Discovery Technologies unit in Espoo, Finland. You will apply AS-MS, native MS, HDX-MS and related MS approaches to study proteins, protein-ligand interactions and mechanisms of action, collaborating with multidisciplinary drug-discovery teams.

You will work at the interface of mass spectrometry, biophysics and structural biology, integrating data to

Qualifications

• Experience in industrial pharma or biotech drug discovery.
• Proven ability to characterize protein–ligand interactions by MS.
• Familiar with MS data acquisition and analysis software.

Responsibilities

• Understand scientific questions and propose MS approaches to drive projects.
• Plan, design and execute MS experiments with AS-MS, native MS, HDX-MS, and related methods.
• Interpret results, assess quality and controls, and document conclusions.
• Integrate MS data with biochemical, biophysical and structural data.
• Communicate MS findings with multidisciplinary teams.
• Collaborate to plan ongoing and upcoming MS studies.
• Provide expert MS guidance in collaborations with external partners.
• Maintain and troubleshoot MS instruments, including HPLC and nanoLC.
• Stay updated on MS developments and identify new methods.

Skills

Protein MS

AS-MS

Native MS

HDX-MS

Peptide mapping

Proteomics

Data interpretation

Tools

Spectronaut

Chronos

DeutEx

UniDec

Protein Metrics

Analytical Studio

HPLC

nanoLC

Job description

Orion Corporation is seeking a curious and collaborative scientist with expertise in protein mass spectrometry to join the Structural Biology and Discovery Technologies unit in Espoo, Finland. You will apply AS-MS, native MS, HDX-MS and related MS approaches to study proteins, protein-ligand interactions and mechanisms of action, collaborating with multidisciplinary drug-discovery teams.

You will work at the interface of mass spectrometry, biophysics and structural biology, integrating data to