Senior Biostatistician: Lead Clinical Trial Strategy

Astrum; Barcelona; On-site; EUR 70,000 - 95,000; Full time

Job summary

Astrum is seeking a Senior Biostatistician in Barcelona to provide statistical leadership across the clinical trial lifecycle, from protocol through regulatory documentation. You will shape endpoints, estimands, sample size, randomization, and risk-based design, collaborating with internal teams and clients.

The ideal candidate holds a university degree in statistics or biostatistics, has at least three years in clinical trial statistics, is fluent in English, and is proficient in SAS;

Qualifications

• University degree in Statistics, Mathematics, or related scientific discipline.
• At least three years of experience in clinical trial statistics.
• Experience developing or reviewing SAPs, CSPs, CSRs, and TFLs.
• Working knowledge of GCP, ICH E3/E6/E9, CDISC standards, regulatory expectations.
• Advanced statistical expertise in mixed-effects models, imputation, adaptive designs, estimand framework.
• Proficiency in SAS is required.
• Experience with Python, R, Git, and SharePoint preferred.
• Excellent written and verbal English skills; business fluency is mandatory.

Responsibilities

• Provide statistical leadership across Phase II–IV clinical studies.
• Develop statistical strategies for trials including sample size, randomization, estimands.
• Author SAPs and review TFLs.
• Review CSPs and CSRs.
• Review programming outputs and analysis datasets.
• Present and defend statistical decisions in client meetings.

Skills

Clinical trial statistics

Statistical leadership

Biostatistics expertise

English communication

Education

Master's or PhD in Statistics/Mathematics/Biostatistics

University degree requirement

Tools

SAS

Python

R

Git

SharePoint

Job description

Astrum is seeking a Senior Biostatistician in Barcelona to provide statistical leadership across the clinical trial lifecycle, from protocol through regulatory documentation. You will shape endpoints, estimands, sample size, randomization, and risk-based design, collaborating with internal teams and clients.

The ideal candidate holds a university degree in statistics or biostatistics, has at least three years in clinical trial statistics, is fluent in English, and is proficient in SAS;