Research Technician

JR Spain; Barcelona; Presencial; EUR 40.000 - 80.000; Jornada completa

Descripción de la vacante

An established industry player is seeking a highly skilled researcher to join their dynamic team in Barcelona. This role focuses on studying DYRK protein kinases, which are crucial for understanding various cancers and developmental disorders. The ideal candidate will have a strong background in molecular biology, expertise in CRISPR-Cas9 techniques, and experience with proteomics data analysis. The position offers a stimulating work environment with state-of-the-art facilities, opportunities for professional development, and a commitment to diversity and inclusion. If you are passionate about scientific research and eager to contribute to groundbreaking discoveries, this opportunity is perfect for you.

Servicios

Flexible Working Hours

Extended Vacation Period

Diverse and Inclusive Environment

Professional Development Opportunities

Formación

• Proven experience in molecular biology techniques and genetic manipulation.
• Strong understanding of protein-protein interaction networks.

Responsabilidades

• Work on DYRK protein kinases and their role in human pathology.
• Conduct experiments involving CRISPR-Cas9 and proteomics data analysis.

Conocimientos

Molecular Biology Techniques

CRISPR-Cas9

Protein Kinases Activity Evaluation

Protein-Protein Interaction Networks

Biotin-Label Proximity Approaches

Proteomics Analysis

Phosphoproteomics Analysis

R Programming

Educación

PhD in Molecular Biology

PhD in Biochemistry

PhD in Biotechnology

Descripción del empleo

The Institute

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated, and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies. In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).

The role

About the lab

The lab works on a family of protein kinases known as DYRK (dual-specificity tyrosine-regulated kinases), whose members - DYRK1A, DYRK1B, DYRK2, DYRK3, DYRK4 - participate in the regulation of processes critical for cell viability and homeostasis. In general, alterations in DYRKs (expression or mutation) are linked to different cancer types. In addition, mutations in several DYRK genes are associated with developmental disorders, such as in the case of the DYRK1A haploinsufficiency syndrome or the DYRK1B-associated metabolic syndrome. The group aims to dissect how DYRK activities are linked to human pathology. We are particularly interested in the DYRK-associated activities that impact the regulation of expression programs either directly on chromatin or indirectly through modulation of signaling pathways.

Whom would we like to hire?

Professional experience

Must Have

1. Proven experience in molecular biology techniques, working with mammalian cells, including genetic manipulation by means of CRISPR-Cas9-based approaches and in evaluating protein kinases activity.
2. You have a good understanding of protein-protein interaction networks.
3. You have proven experience in performing and interpreting biotin-label proximity approaches for interactomic analysis.
4. You are able to generate and analyze proteomics and phosphoproteomics data.
5. Previous experience in working with R programming.

Desirable but not required/ Nice to have

1. First author publication record in international peer-reviewed journals.
2. Experience in performing and interpreting ChIP-Seq and RNA-Seq experiments.

Education and training

You hold a PhD degree in Molecular Biology, Biochemistry, Biotechnology, or similar. PhD Thesis defended from 2021 onwards.

Languages

You are fluent in English, spoken and written.

Competences

1. You have highly developed organization skills.
2. You have dedication, motivation, and rigor in scientific pursuits.
3. You have both the ability to work within a team and independent working skills.
4. You have good training skills in the transfer of technical knowledge to students under training.

The Offer - Working Conditions

1. Contract duration: Contract linked to project (estimated 1 year).
2. Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
3. Target start date: December 1st.

We provide a highly stimulating environment with state-of-the-art infrastructures and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.

We offer and promote a diverse and inclusive environment and welcome applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation, or gender identity. The CRG is committed to reconciling work and family life of its employees and is offering an extended vacation period and the possibility to benefit from flexible working hours.