Regulatory Affairs Senior Specialist EMEA M / F

Zemsania; País Vasco; Presencial; EUR 40.000 - 80.000; Jornada completa

Descripción de la vacante

Un instituto de investigación biomédica de renombre busca un científico postdoctoral motivado para investigar los mecanismos regulatorios del genoma en la diabetes humana. Esta emocionante oportunidad implica el desarrollo de modelos celulares y el uso de métodos genómicos de una sola célula. El candidato ideal tendrá un sólido historial en biología molecular y celular, así como experiencia en tecnologías de edición del genoma. Ofrecemos un entorno de trabajo estimulante con oportunidades únicas de desarrollo profesional y un compromiso con la inclusión y la conciliación de la vida laboral y familiar. Si estás listo para contribuir a investigaciones innovadoras, esta es tu oportunidad.

Servicios

Ambiente de trabajo estimulante

Oportunidades de desarrollo profesional

Períodos de vacaciones extendidos

Horarios de trabajo flexibles

Formación

• Experiencia sólida en biología molecular y celular.
• Experiencia en tecnologías de edición del genoma y análisis de secuencias.

Responsabilidades

• Desarrollar sistemas de modelos celulares para investigar mecanismos genómicos.
• Explorar mecanismos regulatorios del genoma relacionados con la diabetes.

Conocimientos

Biología molecular

Biología celular

Edición del genoma/epigenoma

Métodos genómicos de una sola célula

Análisis de secuencias de nueva generación

Habilidades avanzadas en MS Office

Educación

Doctorado en un campo relevante

Descripción del empleo

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated and creative scientific team supported by a flexible and efficient administration and by high-end and innovative technologies.

In April 2021, the CRG received the renewal of the ‘HR Excellence in Research’ Award from the European Commission. This is a recognition of the Institute’s commitment to developing an HR Strategy for Researchers, designed to align practices and procedures with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers.

The Role

We are seeking a motivated postdoctoral scientist interested in dissecting genome regulatory mechanisms underlying human diabetes. The successful applicant will develop cell-based model systems such as human stem cell-derived beta cells, using single-cell genomic read-outs, and will explore poorly understood genome regulatory mechanisms. The work will be performed within a multidisciplinary lab located in the CRG.

About the Lab

The Regulatory Genomics and Diabetes lab aims to uncover genetic mechanisms causing diabetes mellitus and to develop therapeutic avenues. The group is particularly interested in understanding how genomic information directs cell-specific gene expression and pinpoints gene regulatory defects underlying human disease.

The team brings together diverse expertise, including work with mutant stem cell-derived beta cell organoids, engineered mouse models, single-cell epigenomics, large-scale genetic screens, statistical genetics, and the integration of genetic and regulatory data. This multidisciplinary approach creates unique opportunities for collaborative projects that combine experimental and computational methods. The lab encourages wet lab scientists to engage in their own data analysis and provides a supportive environment for this end. The group is funded by the European Research Council, the Spanish Ministry of Science and Innovation, Generalitat de Catalunya, an AXA chair, European Foundation for the Study of Diabetes, the Marie Skłodowska-Curie Actions program, and a CIBERDEM diabetes network. The lab forms part of international consortia focused on advancing research in regulatory genomics, single-cell genomics, and human genetics.

Recent Studies from the Lab Include :

• A lineage-specific gene transcription and splicing hierarchy disrupted in type 2 diabetes (In review)
• Large-scale discovery of molecular targets for precision treatment of HNF1A-deficient diabetes (In review)
• Transcription regulation by long non-coding RNAs and their disease relevance (Nat Rev Mol Cell Biol, 2024)
• HASTER lncRNA promoter as a cis-acting transcriptional stabilizer of HNF1A (Nat Cell Biol, 2022)
• Pancreas agenesis mutations disrupting a lead enhancer controlling a developmental enhancer cluster (Dev Cell, 2022)
• Human pancreatic islet 3D chromatin architecture providing insights into the genetics of type 2 diabetes (Nat Genet, 2019).

Whom Would We Like to Hire?

Professional Experience

• Solid track record in molecular and cell biology and expertise in one of the following fields: genome / epigenome editing technologies, single-cell genomic methods, or development of protocols with this technology.
• Expertise in next generation sequence analysis.
• A publication track record in these areas with a leading authorship role.

Education and Training

• A PhD in a relevant field.

Technical Skills

• Advanced MS Office skills.

Competences

• Highly developed organizational and communication skills.
• Ability to work in a team.

The Offer – Working Conditions

• Contract duration: Contract for Technical and Scientific Activities – estimated duration of 2 years, with the possibility of renewal.
• Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
• Target start date: January 2025.

We provide a highly stimulating environment with state-of-the-art infrastructures and unique professional career development opportunities.

We offer and promote a diverse and inclusive environment and welcome applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation, or gender identity.

The CRG is committed to reconciling work and family life for its employees and offers an extended vacation period and the possibility to benefit from flexible working hours.

Application Procedure

All applications must include:

• A motivation letter addressed to Dr. Jorge Ferrer.
• Contact details of two referees.

All applications must be addressed to Dr. Jorge Ferrer and submitted online on the CRG Career site.

Selection Process

Pre-selection: The pre-selection process will be based on qualifications and expertise reflected in the candidates' CVs. It will be merit-based.

Interview: Preselected candidates will be interviewed by the Hiring Manager of the position and a selection panel if required.

Offer Letter: Once the successful candidate is identified, the People department will send a Job Offer specifying the start date, salary, working conditions, among other important details.

Deadline: Please submit your application by January 31, 2025.