PhD Researcher - Neurodevelopment & iPSC Disease Modeling

Fundació Sant Joan de Déu; España; On-site; EUR 26,000 - 30,000; Full time

Job summary

Fundació Sant Joan de Déu in Spain seeks a researcher to develop a PhD project focusing on modeling KDM6B-associated neurodevelopmental syndrome, from patient fibroblasts to genome-edited induced pluripotent stem cell lines. The successful candidate will join a multidisciplinary team and advance understanding of disease mechanisms.

Responsibilities include reprogramming fibroblasts, performing CRISPR/Cas9 edits, differentiating iPSCs into neuronal models, and contributing to multi-omics analyses

Qualifications

• Master's degree in Biological Sciences (Biology, Biomedicine, Biochemistry, Genetics or related field).
• Solid background in molecular biology.
• Experience with eukaryotic cell culture; iPSC or iPSC-derived models valued.
• Willingness to learn scripting in R or Python; collaborate with a bioinformatician.

Responsibilities

• Generate and characterize patient-derived fibroblasts.
• Reprogram fibroblasts into iPSCs.
• Perform CRISPR/Cas9 genome editing of iPSC lines.
• Differentiate iPSCs into neuronal models.
• Conduct multi-omics analyses and integrate data.

Skills

English fluency

Teamwork

Autonomy

Scripting (R, Python)

Biology knowledge

Education

Master's degree in Biological Sciences

Tools

R

Python

CRISPR/Cas9

Job description

Fundació Sant Joan de Déu in Spain seeks a researcher to develop a PhD project focusing on modeling KDM6B-associated neurodevelopmental syndrome, from patient fibroblasts to genome-edited induced pluripotent stem cell lines. The successful candidate will join a multidisciplinary team and advance understanding of disease mechanisms.

Responsibilities include reprogramming fibroblasts, performing CRISPR/Cas9 edits, differentiating iPSCs into neuronal models, and contributing to multi-omics analyses