Postdoctoral Fellow in Computational Systems Biology at CIC bioGUNE

CIC bioGUNE (Asociación Centro de Investigación Cooperativa en Biociencias); Derio; Sur place; EUR 30 000 - 40 000; Plein temps

Résumé du poste

The Computational Biology Group at CIC bioGUNE seeks a highly skilled postdoctoral researcher to work on developing computational approaches for designing neuronal cell conversion protocols.

The project aims to create a computational platform to identify hierarchical combinations of cell fate conversion factors to generate specialized neuronal subtypes for cell transplantation therapies in animal models of neurodegenerative diseases.

Qualifications

• Ph.D. degree in computational biology, bioinformatics, biology, computer science, physics or a related discipline.
• Strong computational skills in at least one programming language (e.g. R or Python).
• A strong publication record in related fields.
• Excellent communication and working knowledge in English.

Connaissances

Python

R

Publications

English communication

Formation

Ph.D. in computational biology or related discipline

Outils

Git

Linux

Description du poste

The Computational Biology Group at CIC bioGUNE seeks a highly skilled and motivated postdoctoral researchers to work on an exciting project that aims at the development of computational approaches for designing neuronal cell conversion protocols. The selected candidate will develop a computational platform to identify hierarchical combinations of cell fate conversion factors, which will in turn be used to engineer highly specialized neuronal subtypes for cell transplantation therapies in animal models of Alzheimer's disease, stroke, and epilepsy. To achieve this goal, the candidate will combine a gene network-based approach with a machine learning model (foundational model) to propose protocols for the sequential induction of transcription factors to generate desired cell subtypes. The selected candidate will be part of a Canadian federal grant project (NFRF) with international collaborators who will conduct experimental validation of the computational predictions to translate neuronal reprogramming into clinical practice.

The Computational Biology Group aims at establishing a solid infrastructure to develop theoretical frameworks for computational modeling of biomedical problems, especially in the areas of stem cell research, aging and disease modeling. The group closely collaborates with leading national and international experimental labs with a particular interest in stem cell research and regenerative medicine.

Essential skills and qualities:

• Ph.D. degree in computational biology, bioinformatics, biology, computer science, physics or a related discipline
• Strong computational skills in at least one programming language (e.g. R or Python)
• A strong publication record in related fields
• Excellent communication and working knowledge in English

Ideal skills:

• Prior experience in computational systems biology
• Prior knowledge about transcriptional regulation and the prediction of cellular conversion factors
• Experience in working in a multi-disciplinary research environment

We offer:

• Opportunity to do highly interdisciplinary research to solve complex biomedical problems within a dynamic research institution (CIC bioGUNE) and in collaboration with internationally recognized partner
• An exciting international environment