Scientist - LC-MS Specialist / Analytical Chemistry

Amgen SA; København; Hybrid; DKK 420,000 - 560,000; Full time

Job summary

Amgen Research Copenhagen (ARC) seeks an analytically driven candidate to operate and maintain LC-MS systems and associated prep LC-MS equipment, enabling high-throughput data generation for small molecules and oligo conjugates. You will collaborate across DEL-technology and medicinal chemistry teams to ensure high-quality data and instrument reliability.

The successful candidate will contribute to method development, system validation, and software support across multiple LC-MS platforms, with

Qualifications

• Preferably holds an MSc or BSc in a technical or scientific discipline.
• Experience maintaining and operating LC instruments from multiple suppliers.
• Laboratory technicians with extensive experience may be considered.

Responsibilities

• Daily care of ARC LC-MS and prep LC-MS systems.
• Keep LC and MS instruments in excellent operational state.
• Provide software support for LC and MS software packages.
• Supervise LC-MS users.
• Purify oligo conjugates and other compounds on LC systems.

Skills

LC-MS operation

Mass spectrometry

Analytical chromatography

Team collaboration

Data software

Agilent MassHunter

ChemStation

MassLynx

Shimadzu LabSolutions

Education

MSc or BSc degree

Tools

Agilent MassHunter

ChemStation

MassLynx

Shimadzu LabSolutions

Mnova

ACD Labs

Job description

Amgen is one of the world's leading independent biotechnology companies. For four decades, Amgen has pioneered biotechnology breakthroughs to bringstate-of-the-artmedicines from laboratory to the patient. Amgen Research Copenhagen (ARC),through our DNA Encoded Library (DEL) technology, iscontributing significantly to Amgen's many smallmolecule drug discovery projects from hit discovery all the way to drug candidate selection.

We are currently seeking acandidateto join a team thatoperates, supports, troubleshoots, andmaintainsanalytical instruments, while providing expert instrument guidance to users runningsamples. In addition, the candidate will support the effective use of various LC-MS software packages.

If you are passionate, analytical, resourceful,practical,goal-oriented, open-minded, conscientious, willing to go the extra mile, enjoy working in the lab in a dynamic environment, and have a desire to contribute to groundbreaking scientific research within a new field of drug discovery, we may have a position for you.

As a member of the Analytics team,you will help us setup and operate LC-MSsystems and various automated sample preparation equipment to ensurehigh-throughput acquisition, analysis and purification of small molecule including oligo conjugates to deliverhigh-qualitydata, take part in method development and implementation of new analytic instruments. The position will primarily involve maintenance and setup of LC-MS systems, but also method development and testing of new setups. You will be working cross-functionally with internal groups specializing in DEL-technology, parallel synthesis, medicinal chemistry and biology, and you willparticipatewith your analyticalexpertisein the process of identifyingand purifying various compounds.

Specifically, tasks will include:

• Daily care of ARC analytical and prep LC-MS.
• Keeping LC and MS instruments, including CLNDdetectors, in excellent operational state.
• Software support for all LC and MS based software package
• Supervision of LC-MS users
• Purification of oligo conjugates and other compounds on LC systems
• Keeping track of spare parts for all instruments

We offer a highly rewarding and stimulating environment in a world-class drug discovery organization.The position is based across our two Østerbro offices, 1.3 km apart,about 4minutes bybike.

The employee will report to ScientificAssociateDirector, MichaelGodskesen. For further information contact HRSr Manager,Rachel Allen ([e-mail])

Qualifications

Preferably, the candidate should hold an M.Sc. or B.Sc. degree in a relevant technical or scientific discipline and have at least three years of experiencemaintainingand operating LC instruments from multiple suppliers. Laboratory technicians with at least ten years of relevant experience and well-documented training may also be considered.

The ideal candidate will have

• Proficiency in running analytical as well as preparative samples on various LC-MS platforms
• In depth understanding of liquid chromatography and Mass Spectrometry
• On hands experience working and maintenance of different LC-MS systems
• Competence related to manual and automated sample preparation
• Proficiency in AgilentChemStation and MassHunter software
• Familiaritywith Waters MassLynx software
• Knowledge of Shimadzu LabSolutions software
• Experience working with third party analytical software ACD Labs, Mnova or similar
• A talent for tidiness, data organization etc.
• Excellent collaboration and team player skills
• Thrives in a fast-changing environment where priorities and location can change throughout the day
• Excellent English communication skills
• A confident communicator committed to delivering high-quality results