GPCR Peptide Design Scientist: Next-Gen Therapeutics

Black Swans Exist ApS; København; On-site; DKK 900,000 - 1,100,000; Full time

Job summary

Black Swans Exist ApS in Copenhagen is seeking an exceptional peptide drug design scientist with deep expertise in GPCR agonist peptide design and optimization. You will lead molecular design of ~40 amino acid peptide agonists, drive second-generation candidates, and collaborate across discovery and development in a fast-moving biotech environment.

The role emphasizes scientific excellence, IP, and hands-on problem solving, with responsibility to guide design-test-learn cycles and work with CROs

Qualifications

• Strong track record in peptide therapeutic discovery, ideally including GPCR agonist programs.
• Deep expertise in peptide engineering and receptor pharmacology.
• Excellent project management skills, with hands-on problem solving.

Responsibilities

• Drive design and optimization of second-generation peptide agonists targeting a Class B GPCR.
• Lead SAR and molecular engineering to improve potency, efficacy, selectivity, stability, PK/PD and half-life.
• Design differentiated analogs guided by strong scientific rationale and experimental insight.
• Collaborate with biology, pharmacology, and formulation teams to support rapid design-test-learn cycles.
• Integrate pharmacology, formulation, and DMPK insights to guide iterative optimization.
• Collaborate with CROs and external partners across discovery and development activities.
• Generate and evaluate novel scientific hypotheses with data-driven mindset.
• Support IP generation alongside CSO and VP of IP.

Skills

GPCR design

Peptide engineering

SAR analysis

IP awareness

Project management

Education

PhD in peptide/medicinal chemistry

Related discipline

Job description

Black Swans Exist ApS in Copenhagen is seeking an exceptional peptide drug design scientist with deep expertise in GPCR agonist peptide design and optimization. You will lead molecular design of ~40 amino acid peptide agonists, drive second-generation candidates, and collaborate across discovery and development in a fast-moving biotech environment.

The role emphasizes scientific excellence, IP, and hands-on problem solving, with responsibility to guide design-test-learn cycles and work with CROs