Senior Scientist - Structural Biology (m/f/d)

WuXi AppTec Group; München; Hybrid; EUR 70,000 - 110,000; Full time

Job summary

WuXi AppTec Group in Munich, Germany, seeks an experienced structural biologist with X-ray crystallography expertise to support early-stage drug discovery. You will plan structural biology projects, crystallization experiments, and X-ray data processing to solve protein–ligand structures, and communicate results to clients.

The role requires a PhD in biology/chemistry-related field, strong software experience (CCP4, XDS, PyMOL, ChimeraX) and familiarity with Linux environments, with

Qualifications

• PhD in Biology, Biochemistry, Chemistry or related field.
• Practical knowledge of construct design, crystallization and structure determination using standard software.
• Experience with cryo-EM, fragment screening or protein design is advantageous.
• Experience with Bash/Python, SQL/MariaDB and Linux systems is a strong advantage.

Responsibilities

• Plan and run structural biology projects focused on structure-based drug design.
• Plan crystallization and data collection, determine structures of protein–ligand complexes.
• Communicate results clearly in internal and external teams.
• Document protocols and results carefully.
• Plan work to meet timelines and stay updated on advances in the field.
• Maintain up-to-date knowledge of structural biology advances.

Skills

Interdisciplinary teamwork

English proficiency

German knowledge (ideally)

Education

PhD in Biology/Biochemistry/Chemistry or related

Tools

Global Phasing

CCP4

XDS

PyMOL

ChimeraX

Bash

Python

SQL/MariaDB

Linux administration

Job description

Overview

We are looking for an experienced structural biologist with a background in X-ray crystallography to join the growing Structural Biology group based in Munich, Germany. In close collaboration with the various departments at Crelux you will provide structural biology support for early-stage drug discovery projects covering a wide range of target classes. Your main responsibilities will include the planning of structural biology projects and crystallization experiments, X-ray crystallography data processing and structure determination of protein-ligand complexes, and the communication of results to our clients.

Responsibilities

• Planning and running structural biology client projects with a focus on structure-based drug design in early-stage drug discovery projects
• Planning of crystallization and data collection experiments as well as the determination of X-ray crystal structures (typically protein-ligand complexes)
• Professional written and verbal communication of scientific results in internal and external project teams
• Careful documentation and evaluation of scientific protocols and results
• The ability to plan work to meet planned timelines
• Maintain an up-to-date knowledge of scientific advances in structural biology

Qualifications

• PhD in Biology, Biochemistry, Chemistry or a related subject
• Practical and theoretical knowledge of construct design, crystallization, and structure determination using standard software packages (in particular Global Phasing, CCP4, XDS, PyMOL and ChimeraX) running on Linux
• Experience in any of the following areas would be highly advantageous – cryo-electron microscopy, crystallographic fragment screening, protein design
• Experience with programming (Bash and Python), databases (SQL/MariaDB) and/or administration of Linux systems would be a strong advantage
• Excellent interpersonal skills and the ability to work and communicate efficiently in interdisciplinary teams
• Fluent spoken and written English and (ideally) German