Senior Clinical Trial Manager - Oncology (Europe)

Worldwide Clinical Trials; Deutschland; Remote; EUR 90,000 - 130,000; Full time

Job summary

Worldwide Clinical Trials seeks a Senior Clinical Trial Manager to oversee site management across studies and regions, ensuring quality and regulatory compliance. You will partner with project management, sponsors, CRAs, and cross‑functional teams to drive study performance and monitoring strategies.

You will mentor site management teams, manage risks, and ensure timely TMF/CMF review while supporting recruitment and operational excellence in a remote European setting.

Qualifications

• Four‑year college curriculum with health major and 4+ years in a Senior CRA/CTM role.
• Alternatively, 2‑year degree with 6+ years in a Senior CRA/CTM track is acceptable.
• Minimum 2 years leading a CTM/LCRA team on oncology studies.
• Solid knowledge of FDA/EU regulations, ICH guidelines and SOPs.
• Experience overseeing monitoring and site management in trials.

Responsibilities

• Lead clinical site management from startup to closeout across studies.
• Develop monitoring strategies with project management to hit targets.
• Mentor CRAs and site teams; coordinate sponsor meetings and audits.
• Ensure Trial Master File and study documentation are complete and compliant.
• Monitor metrics, recruitment, risks, and implement mitigation plans.

Skills

Leadership

Remote team management

Oncology experience

Regulatory knowledge

Problem solving

Education

BSc in life sciences / biology

Nursing degree or life science degree (preferred)

Tools

EDC systems

CTMS

IxRS/IVRS

eCRF platforms

MS Office

Job description

Who We Are

We’re a global, midsize CRO that pushes boundaries, innovates and invents because the path to a cure for the world’s most persistent diseases is not paved by those who play it safe. It is built by those who take pioneering, creative approaches and implement them with quality and excellence.

Who We Are

We’re a global, midsize CRO that pushes boundaries, innovates and invents because the path to a cure for the world’s most persistent diseases is not paved by those who play it safe. It is built by those who take pioneering, creative approaches and implement them with quality and excellence.
We are Worldwide Clinical Trials, and we are a global team of over 3,500+ experts, bright thinkers, dreamers and doers and, together, we are changing the way the world experiences CROs – in the best possible way.
Our mission is to work with passion and purpose every day to improve lives and we are looking for others who value this same pursuit.

Why Worldwide

We believe everyone plays an important role in making a world of difference for patients and their caregivers. From our hands‑on, accessible leaders, to our cohesive and supportive teams, we are committed to enabling professionals from all backgrounds and experiences to succeed. We prioritize cultivating a diverse and inclusive environment that continues to promote collaboration and creativity. We are proud to be a workplace where people thrive by being themselves and are inspired to do their best work every day. Join us!

Make an Impact as a Senior Clinical Trial Manager at Worldwide

As a Senior Clinical Trial Manager, you will lead the delivery of critical clinical site management activities across studies and regions, helping ensure research is conducted with quality, efficiency, and compliance at every stage. Your leadership will directly support the successful execution of clinical trials and contribute to bringing new therapies to patients.
In this role, you will partner closely with project management, sponsors, CRAs, and cross‑functional teams to drive study performance, oversee monitoring strategies, and ensure sites are supported from qualification through closeout. You'll play a pivotal role in risk management, team leadership, operational excellence, and the delivery of high-quality clinical outcomes.
You will also serve as a key point of contact for sponsors and study teams, providing strategic oversight, mentoring site management teams, and ensuring clinical operations remain aligned with study goals, timelines, and quality expectations.

Where You'll Work

This is a remote role open to candidates based in Europe. You will collaborate with global teams across multiple time zones.
Travel will be required on an as‑needed basis.

• Lead and coordinate clinical site management activities from study startup through database lock and study closeout.
• Partner with project management to develop monitoring strategies, establish site management targets, and ensure delivery against project goals.
• Provide leadership, guidance, and oversight to CRAs and site management team members across assigned studies and regions.
• Serve as the primary site management representative for sponsors, study teams, investigator meetings, audits, inspections, and key project discussions.
• Drive quality and compliance by overseeing monitoring activities, reviewing protocol deviations, ensuring adherence to Clinical Monitoring Plans, and maintaining inspection readiness.
• Monitor study metrics, recruitment performance, resource allocation, and operational trends to identify risks and implement effective solutions.
• Support patient recruitment efforts by tracking enrollment progress and guiding site‑specific recruitment strategies to maintain study targets.
• Ensure Trial Master File compliance and oversee the timely completion and quality review of site management documentation.
• Proactively identify, elevate, and mitigate operational and monitoring risks while supporting issue resolution and continuous improvement initiatives.

What You'll Bring

• Four‑year college curriculum or equivalent with a major concentration in biological, physical or health studies and a minimum experience of 4 years as a Senior Clinical Research Associate (or equivalent), OR
• Two‑year college curriculum or equivalent education/training (nursing degree or equivalent life science degree preferred) and a minimum experience of 6 years as a Senior Clinical Research Associate, AND
• Minimum 2 years relevant experience as a CTM/LCRA (or equivalent) including overseeing a CTM team.
• Experience working with Oncology studies is required for this role.
• Experience leading or coordinating clinical monitoring and site management activities within clinical trials.
• Strong understanding of clinical research principles, site management processes, and monitoring best practices.
• Knowledge of FDA and/or EU regulations, ICH Guidelines, local regulatory requirements, and clinical trial SOPs.
• Experience reviewing study metrics, managing operational risks, supporting recruitment activities, and maintaining high-quality study documentation.
• Proficiency with Microsoft Office and clinical systems including EDC, CTMS, IxRS/IVRS, and eCRF platforms.
• Demonstrated ability to lead and motivate remote teams, influence stakeholders, solve complex problems, and manage multiple priorities effectively.
• Proficiency in English, with excellent written, verbal, presentation, and interpersonal communication skills.

We love knowing that someone is going to have a better life because of the work we do.

To view our other roles, check out our careers page at Discover a world of difference at Worldwide! For more information on Worldwide, visit www.Worldwide.com or connect with us on LinkedIn.

Worldwide is an equal opportunity employer that is committed to enabling professionals from all backgrounds and experiences to succeed and, to that end, we prioritize attracting diverse talent and cultivating an inclusive environment that encourages collaboration and creativity. We know that when our employees feel appreciated and included, they can be more creative, innovative, and successful. We’re on a mission to hire the very best and are committed to creating exceptional employee experiences where everyone is respected and has access to equal opportunity. We provide equal employment opportunities to all employees and applicants regardless of race, color, ethnicity, ancestry, religion, national origin, gender, sex, gender identity or expression, sexual orientation, age, citizenship, marital or parental status, disability, military status, or other class protected by applicable law.