Research Opportunities - Cardiology

Washington University in St. Louis; Berlin; On-site; EUR 40,000 - 58,000; Full time

Job summary

Washington University in St. Louis, Sah laboratory, is seeking a researcher to study TRP and LRRC8 ion channel regulation using patch-clamp, imaging, and genetic mouse models.

The role focuses on metabolism-related signaling in cardiac and skeletal muscle, adipose tissue and endothelium, integrating medicinal chemistry with cryo-EM and molecular docking. The laboratory aims to understand how ion channels and mechano-signaling influence cellular function, with opportunities to contribute to

Qualifications

• Strong background in cell biology and protein biochemistry with an interest in electrophysiology and ion channel biology.
• Working knowledge of computer software (Excel, Photoshop, and Prism) and general lab equipment.
• Demonstrated ability to work independently and communicate effectively.
• Troubleshooting skills.
• Ability to maintain complete and organized records.
• Effective verbal, written and interpersonal communication skills.

Skills

Cell biology

Protein biochemistry

Electrophysiology interest

Ion channel biology

Independent work

Communication

Education

Bachelor's degree

Tools

Excel

Photoshop

Prism

Job description

Location

SAINT LOUIS, MO 63110

Scheduled Hours

40

Position Summary

The Sah laboratory at WashU Medicine in St. Louis (Department of Internal Medicine, Cardiology) and the Center for the Investigation of Membrane Excitability Disease (CIMED) studies the mechanisms of Transient Receptor Potential (TRP) and LRRC8a/ SWELL1 ion channel regulation and signal transduction. The laboratory uses electrophysiological (e.g., patch-clamp), imaging techniques, genetic mouse models (including CRISPR/cas9 technology), biochemical, and molecular approaches to investigate the regulation of signal transduction mechanisms of novel ion channels, including TRP/LRRC8 channels, in cardiac muscle, skeletal muscle, adipose tissue, and endothelium and pancreatic islet cells.

Broadly speaking, the overarching goal of the Sah laboratory is to understand how ion channels and mechano-signaling influence cellular and organismal metabolism. We also combine medicinal chemistry with cryo-EM structure, molecular docking, and functional studies to guide synthesis of novel ion channel modulators for the treatment of human disease.

Job Description

Primary Duties & Responsibilities:

Working Conditions:

A laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment, provide standard care to research animals, and handle human biosamples.

Salary Range:

Base pay is commensurate with experience.

The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.

Required Qualifications

Education:

Bachelor’s degree or combination of education and/or experience may substitute for minimum education.

Certifications /Professional Licenses :

No specific certification/professional license is required for this position.

Work Experience:

No specific work experience is required for this position.

Skills:

Not Applicable

Driver’s License:

A driver’s license is not required for this position.

More About This Job

Preferred Qualifications:

• Strong background in cell biology and protein biochemistry with an interest in electrophysiology and ion channel biology.

• Working knowledge of computer software (Excel, Photoshop, and Prism) and general lab equipment.

• Demonstrated ability to work independently and communicate effectively.

• Troubleshooting skills.

• Ability to maintain complete and organized records.

• Effective verbal, written and interpersonal communication skills.

Preferred Qualifications

Education:

No additional education unless stated elsewhere in the job posting.

Certifications/Professional Licenses** :**

No additional certification/professional licenses unless stated elsewhere in the job posting.

Work Experience:

No additional work experience unless stated elsewhere in the job posting.

Skills:

Communication, Laboratory Research, Organizing, Recordkeeping, Working Independently

Grade

00

Questions

For frequently asked questions about the application process, please refer to our External Applicant FAQ.

Accommodation

If you are unable to use our online application system and would like an accommodation, please email [e-mail] or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request.

All qualified individuals must be able to perform the essential functions of the position satisfactorily and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job, absent undue hardship.

Pre-Employment Screening

All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.

Benefits Statement

Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.

EEO Statement

Washington University in St. Louis is committed to the principles and practices of equal employment opportunity. It is the University’s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, citizenship (where prohibited by federal law), age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information.