Research Associate for Structural biology and biochemistry § 28 Subsection 1 HmbHG

Universität Hamburg; Hamburg; Vor Ort; EUR 40.000 - 60.000; Vollzeit

Zusammenfassung

A leading research university in Hamburg seeks a research associate to engage in teaching and investigating how antibiotics affect ribosome functions. Candidates should possess a relevant degree and experience with biochemical methods. This role offers reliable remuneration, flexible working hours, and numerous professional development opportunities. Embrace equity and diversity by applying at this esteemed institution.

Leistungen

Reliable remuneration based on wage agreements

Continuing education opportunities

30 days of vacation per annum

Flexible working hours

Health management, EGYM Wellpass

Qualifikationen

• University degree related to biology or biochemistry.
• Experience with biochemical methods like PCR and protein purification.
• Familiarity with structural biology approaches advantageous.

Aufgaben

• Teach and conduct research on antibiotic interactions with ribosomes.
• Prepare samples for cryo-EM and analyze data for findings.
• Conduct academic work including doctoral dissertation.

Kenntnisse

PCR

Cloning

Protein expression

Protein purification

Single-particle cryo-EM

Ausbildung

University degree in a relevant field

Jobbeschreibung

Responsibilities

Research associates will be expected primarily to teach and conduct research. The research associate will also have the opportunity to pursue further academic qualifications, in particular a doctoral dissertation. At least one-third of set working hours will be made available for the research associate’s own academic work.

The main goal is to understand how antibiotics inhibit the ribosome and protein synthesis and how bacteria obtain resistance to these classes of ribosome‑targeting antibiotics. To do this, the applicant will use biochemical approaches to form appropriate complexes between the antibiotics and the ribosome that can then be interrogated using structural biology approaches, such as single‑particle cryo‑EM. In addition, ribosome complexes will be formed with protein factors that confer antibiotic resistance or using ribosomes that contain mutations or modifications that confer antibiotics resistance. These complexes will then also be analyzed using single‑particle cryo‑EM approaches. Teaching hours 2,6.

The applicant will undergo training in sample preparation for cryo‑EM as well as data collection and processing methodologies for single‑particle cryo‑EM.

Profile

A university degree in a relevant field.

Experience with biochemical and molecular biology methods such as PCR, cloning, protein expression, and protein purification.

Experience with ribosomes, RNA and/or structural biology approaches, especially single‑particle cryo‑EM, would be an advantage.

We offer

• Reliable remuneration based on wage agreements
• Continuing education opportunities
• University pensions
• Attractive location
• Flexible working hours
• Work‑life balance opportunities
• Health management, EGYM Wellpass
• Educational leave
• 30 days of vacation per annum

Universität Hamburg—University of Excellence is one of the strongest research educational institutions in Germany. Our work in research, teaching, educational and knowledge exchange activities is fostering the next generation of responsible global citizens ready to tackle the global challenges facing us. Our guiding principle “Innovating and Cooperating for a Sustainable Future in a digital age” drives collaboration with academic and nonacademic partner institutions in the Hamburg Metropolitan Region and around the world. We would like to invite you to be part of our community to work with us in creating sustainable and digital change for a dynamic and pluralist society.

The University of Hamburg is committed to equity. Diversity enriches our university life, whether in our studies, research, teaching, education, or workplace. We therefore welcome all applications, regardless of gender, gender identity, sexual orientation, ethnic or social background, age, religion or belief, disability, or chronic illness.

The University of Hamburg strives to increase the number of women in academia, and encourages qualified female academics to apply.

Severely disabled and disabled applicants with the same status will receive preference over equally qualified non-disabled applicants.