PostDoc in Molecular and Oncological Gynecology - Klinik für Frauenheilkunde und Geburtshilfe

Universitätsklinikum Frankfurt; Frankfurt; Vor Ort; EUR 45.000 - 60.000; Teilzeit

Zusammenfassung

A leading University Hospital in Germany is seeking a Postdoctoral Researcher for an innovative project in ovarian cancer research, focusing on IVT-mRNA delivery and therapeutic strategies. The ideal candidate must have expertise in mouse models and a FELASA Certificate. This role offers part-time employment options and various benefits, including free public transport and professional development opportunities.

Leistungen

Childcare services

Free public transport

Professional development training

Health offers and courses

Qualifikationen

• Expertise in different mouse models, tumor injection, and in vivo treatments.
• Knowledge of combination therapies and targeted inhibition.
• Valid proof of measles immunity required.

Aufgaben

• Conduct research on IVT-mRNA in ovarian cancer.
• Perform mouse model experiments and assess tumor response.
• Develop and implement therapeutic strategies.

Kenntnisse

Mouse model experiments

Bioluminescence-based tumor imaging

Oncological therapeutic approaches

Ausbildung

FELASA Certificate

Jobbeschreibung

Overview

The Department of Molecular and Oncological Gynecology at the University Hospital Frankfurt invites applications for a Postdoctoral Researcher position to join an innovative project investigating IVT-mRNA-based reactivation of tumor suppressor pathways in ovarian cancer. The project focuses on developing and preclinical validation of next-generation lipid nanoparticle (LNP) carriers for IVT-mRNA delivery, functionalized and non-functionalized with antibodies. Studies will use patient-derived organoids and in vivo models, including orthotopic and metastatic ovarian cancer mouse models and PDX models, to improve targeted therapy and translational application.

Universitätsmedizin Frankfurt is a leading University Clinic with diverse, international collaboration and a commitment to combining patient care, research and teaching.

Responsibilities

• Conduct in-depth research into the role of IVT-mRNA in the restoration of tumor-suppressor genes in ovarian cancer and reversing therapy resistance.
• Perform mouse model experiments, including tumor induction, in vivo drug treatment, and assessment of tumor response using bioluminescence imaging.
• Develop patient-derived organoid cultures.
• Perform functional assays to assess cell viability, proliferation, apoptosis, and drug sensitivity in cancer models.
• Develop and implement innovative therapeutic strategies, including combination treatments with targeted IVT-mRNA and cisplatin.
• Collaborate with a multidisciplinary team of researchers and clinicians to interpret experimental results and drive the research forward.

Qualifications

• Expertise in working with different mouse models, including tumor injection, intraperitoneal and intravenous treatment of mice, and in vivo treatments.
• Expertise in working with bioluminescence-based tumor imaging in vivo is highly desirable.
• FELASA Certificate is mandatory for the position.
• Knowledge of oncological therapeutic approaches, including combination therapies and targeted inhibition.
• Due to legal regulations, valid proof of measles immunity / measles vaccination is required.

Additional Information

• Part-time employment is possible; we offer childcare in our daycare center (contact UKF-Familienservice) and childcare during holidays.
• Free public transport in all Hessen (Free State Ticket Hessen).
• Internal and external training for professional development.
• Attractive salary based on a collective agreement with an annual special payment and long-term security through pension schemes.
• Health offers with regular online and in-person courses on nutrition, relaxation, sports and exercise.
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