Postdoc - Characterization of CHO Host Cell Proteins

Boehringer Ingelheim; Biberach an der Riß; Vor Ort; EUR 55.000 - 70.000; Teilzeit

Zusammenfassung

Boehringer Ingelheim invites applications for a part-time postdoctoral role in downstream process development and analytics. Work at the frontier of bioprocessing science, focusing on host cell proteins from CHO cells to advance biologics development.

You will use mass spectrometry, protein analytics, and recombinant protein expression to study HCP behavior, collaborate with teams, lead projects, supervise students, and contribute to data-driven risk mitigation.

Qualifikationen

• PhD in Biochemistry, Biotechnology, Bioengineering, Chemical Engineering, Biology, or a related scientific discipline.
• Strong expertise in protein biochemistry and molecular characterization, ideally including experience with host cell proteins (HCPs).
• Hands-on experience with mass spectrometry-based protein identification and quantification methods, preferably with a focus on host cell protein analysis.
• Experience in MS data processing and analysis using bioinformatics tools, including both raw and processed datasets; knowledge of recombinant protein expression and purification is highly desirable.
• Solid understanding of downstream processing concepts, chromatography principles, and data-driven experimental design and quantitative data analysis.
• Proven ability to work independently and collaboratively in multidisciplinary teams, supported by a strong scientific publication record and excellent English communication, scientific writing, and documentation skills.

Aufgaben

• Characterize and investigate CHO host cell proteins, focusing on critical and difficult-to-remove species that may affect downstream processing and product stability.
• Using advanced mass spectrometry-based approaches, identify, quantify, and profile host cell proteins and support impurity risk assessment through data-driven analyses.
• Establish, optimize, and apply analytical and functional assays to evaluate host cell protein behavior at trace levels throughout different purification stages.
• Through recombinant protein expression strategies, enable the in-depth characterization of selected host cell proteins under controlled experimental conditions.
• Collaborate with downstream process development and analytics to investigate interactions between host cell proteins and therapeutic proteins and translate findings into risk mitigation strategies.
• As principal investigator for research and technology projects, lead scientific studies, oversee project execution and data interpretation, supervise students and technical staff, and communicate results effectively to stakeholders and management.

Kenntnisse

Protein biochemistry

Mass spectrometry

MS data analysis

Bioinformatics tools

English communication

Ausbildung

PhD in Biochemistry or related field

Tools

Mass spectrometry tools

Jobbeschreibung

Work at the forefront of innovative bioprocessing science and help shape the future of biopharmaceutical development!

Seize the opportunity to make a significant contribution to the understanding and control of host cell proteins originating from CHO cells, a key challenge in biologics development. Join our dynamic downstream process development & analytics team and use your scientific expertise to drive innovation at the interface of protein analytics, process development, and product quality.

Your expertise and commitment are our key to success!

This position is part time eligible with 80 %

Postdoc: This Position is limited for 2 years. Note: To make it easier to find our job advertisements, we use the usual designation "postdoc". Of course, this advertisement is not only addressed to applicants directly after completing their doctorate, but to all qualified candidates.

The Position

Work at the forefront of innovative bioprocessing science and help shape the future of biopharmaceutical development!

Seize the opportunity to make a significant contribution to the understanding and control of host cell proteins originating from CHO cells, a key challenge in biologics development. Join our dynamic downstream process development & analytics team and use your scientific expertise to drive innovation at the interface of protein analytics, process development, and product quality.

Your expertise and commitment are our key to success!

Discover our Biberach site: xplorebiberach.com

This position is part time eligible with 80 %

Postdoc: This Position is limited for 2 years. Note: To make it easier to find our job advertisements, we use the usual designation "postdoc". Of course, this advertisement is not only addressed to applicants directly after completing their doctorate, but to all qualified candidates.

Tasks & responsibilities

• You will characterize and investigate CHO host cell proteins, with a particular focus on critical and difficult-to-remove species that may affect downstream processing and product stability
• Using advanced mass spectrometry-based approaches, you will identify, quantify, and profile host cell proteins and support impurity risk assessment through data-driven analyses
• You will establish, optimize, and apply analytical and functional assays to evaluate host cell protein behavior at trace levels throughout different purification stages
• Through recombinant protein expression strategies, you will enable the in-depth characterization of selected host cell proteins under controlled experimental conditions
• In close collaboration with downstream process development and analytics, you will investigate interactions between host cell proteins and therapeutic proteins and translate findings into risk mitigation strategies
• As principal investigator for research and technology projects, you will lead scientific studies, oversee project execution and data interpretation, supervise students and technical staff, and communicate results effectively to stakeholders and management

Requirements

• PhD in Biochemistry, Biotechnology, Bioengineering, Chemical Engineering, Biology, or a related scientific discipline
• Strong expertise in protein biochemistry and molecular characterization, ideally including experience with host cell proteins (HCPs)
• Hands-on experience with mass spectrometry-based protein identification and quantification methods, preferably with a focus on host cell protein analysis
• Experience in MS data processing and analysis using bioinformatics tools, including both raw and processed datasets; knowledge of recombinant protein expression and purification is highly desirable
• Solid understanding of downstream processing concepts, chromatography principles, and data-driven experimental design and quantitative data analysis
• Proven ability to work independently and collaboratively in multidisciplinary teams, supported by a strong scientific publication record and excellent English communication, scientific writing, and documentation skills

As part of our commitment to transparency and fairness, salary information will be shared during the recruitment process. We also offer a comprehensive benefits and wellbeing package.

Applications from persons with severe disabilities are warmly welcomed. In cases of equal qualifications, such applicants will be given preferential consideration in the selection process.

Recruitment process

Step 1: Online application - The job posting is presumably online until September 25, 2026

Step 2: Virtual meeting in the period from end of September till end of October

Step 3: On-site interviews beginning of November

Our Company

Boehringer Ingelheim is a biopharmaceutical company active in both human and animal health. As one of the industry's top investors in research and development, the company focuses on developing innovative therapies that can improve and extend lives in areas of high unmet medical need. Independent since its foundation in 1885, Boehringer takes a long-term perspective, embedding sustainability along the entire value chain. Our approximately 54,300 employees serve over 130 markets to build a healthier and more sustainable tomorrow. Learn more at www.boehringer-ingelheim.com.

Why Boehringer Ingelheim?

With us, you can develop your own path in a company with a culture that knows our differences are our strengths - and break new ground in the drive to make millions of lives better.

Here, your development is our priority. Supporting you to build a career as part of a workplace that is independent, authentic and bold, while tackling challenging work in a respectful and friendly environment where everyone is valued and welcomed.

Alongside, you have access to programs and groups that ensure your health and wellbeing are looked after - as we make major investments to drive global accessibility to healthcare. By being part of a team that is constantly innovating, you'll be helping to transform lives for generations.

Want to learn more? Visit https://www.boehringer-ingelheim.com