Post-doctoral researcher (m/f/d)

Universitätsklinikum Jena; Deutschland; Sur place; EUR 58 000 - 72 000; Plein temps

Avantages offerts par ce poste

TV-L pay grade E13

Free continuing education

Company pension

Health services

Family-friendly measures

Assistance in apartment

Cafeteria

Daycare

Résumé du poste

Universitätsklinikum Jena invites applications for a Postdoctoral researcher in the Functional Proteome Analysis Working Group. The project focuses on ultra-sensitive mass spectrometry-based phosphoproteomics to study how drugs affect patient tumor proteomes.

You will build a scalable platform for high-dimensional perturbation experiments in primary cells and analyze large phosphoproteomics datasets using R or Python.

Qualifications

• PhD in (bio)chemistry, molecular biology, systems biology, or a related field.
• Theoretical knowledge and practical skills in mass spectrometry-based proteomics, ideally with hands-on experience in low-input phosphoproteomics.
• Demonstrated experience with mammalian cell culture and sample preparation for MS analysis.
• Ability to independently develop and troubleshoot MS-based proteomics workflows.
• Proficiency in R or Python for analyzing omics datasets, including statistical analysis and integration of multiple datatypes.
• Strong track record of scientific excellence and high-quality first-author publications.

Responsabilités

• Make key contributions to ERC Starting Grant project 'PerturbPhos' by developing ultra-sensitive MS-based phosphoproteomics technologies.
• Build and optimize a scalable phosphoproteomics platform for high-dimensional perturbation experiments of primary cells.
• Analyze large-scale (phospho)proteomics datasets using R or Python to integrate prior knowledge and characterize drug-induced phosphorylation changes.
• Collaborate effectively across clinicians, biologists, and bioinformaticians.
• Disseminate project results through presentations and manuscripts.

Connaissances

Phosphoproteomics

Mass spectrometry

Cell culture

R/Python

Team collaboration

Scientific writing

English proficiency

Troubleshooting workflows

Formation

PhD in bio-chemistry / molecular biology / systems biology

Description du poste

Functional Proteome Analysis Working Group

Organisation/Company Universitätsklinikum Jena Department Functional Proteome Analysis Working Group Research Field Biological sciences » Biology Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Application Deadline 9 Nov 2026 - 06:00 (Europe/Berlin) Country Germany Type of Contract Temporary Job Status Full-time Hours Per Week 40 Is the job funded through the EU Research Framework Programme? Other EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Welcome to Jena University Hospital!

We are Thuringia's only university hospital:

Patient care, research and teaching go hand in hand here. We treat more than 520,000 patients every year in our 32 clinics and polyclinics.

Their satisfaction is our goal. This is what our more than 6,800 employees work towards every day.
Primary Duties & Responsibilities:

• Make key contributions to the ERC Starting Grant funded project "PerturbPhos" (Grant agreement ID: 101222284), developing ultra-sensitive mass spectrometry (MS)-based phosphoproteomics technologies to study how drugs affect a patient's tumor proteome
• Build and optimize a scalable phosphoproteomics platform tailored to high-dimensional perturbation experiments of primary cells
• Analyze large-scale (phospho)proteomics datasets using R or Python-based computational tools to integrate prior knowledge and characterize drug-induced phosphorylation changes
• Work and communicate efficiently across inter-professional teams
• Disseminate project results through presentations and manuscripts.

Required Skills & Qualifications:

• PhD in (bio)chemistry, molecular biology, systems biology, or a related field
• Theoretical knowledge and practical skills in mass spectrometry-based proteomics, ideally with hands-on experience in low-input phosphoproteomics
• Demonstrated experience with mammalian cell culture and sample preparation for MS analysis
• Ability to independently develop and troubleshoot MS-based proteomics workflows
• Prior experience with clinical patient material and/or characterizing small molecule drugs is desired
• Proficiency in R or Python for analyzing omics datasets, including statistical analysis and integration of multiple datatypes
• Strong track record of scientific excellence (e.g., high-quality first-author publications), rigorous research practice, and commitment to research integrity
• Strong ability work and communicate effectively in interdisciplinary teams (clinicians, biologists, bioinformaticians)
• Strong scientific writing and presentation skills in English.

We offer:

• Classification is based on TV-L in pay grade E13 if the personal and collective agreement requirements are met
• free continuing education
• company pension
• health services
• family-friendly measure
• assistance in apartment
• cafeteria
• Company-sponsored daycare

Reference number: DM20/2026

* Limited to 24 months, with an option to extend

Regardless of origin, age, gender or disability - you are welcome here at Jena University Hospital.

PhD in (bio)chemistry, molecular biology, systems biology, or a related field

Theoretical knowledge and practical skills in mass spectrometry-based proteomics, ideally with hands-on experience in low-input phosphoproteomics

Demonstrated experience with mammalian cell culture and sample preparation for MS analysis

Specific Requirements

Ability to independently develop and troubleshoot MS-based proteomics workflows

Prior experience with clinical patient material and/or characterizing small molecule drugs is desired

Proficiency in R or Python for analyzing omics datasets, including statistical analysis and integration of multiple datatypes

Strong track record of scientific excellence (e.g., high-quality first-author publications), rigorous research practice, and commitment to research integrity

Strong ability work and communicate effectively in interdisciplinary teams (clinicians, biologists, bioinformaticians)

Strong scientific writing and presentation skills in English.

Languages ENGLISH Level Excellent

Research Field Biological sciences

Additional Information

• Classification is based on TV-L in pay grade E13 if the personal and collective agreement requirements are met