PhD Student (gn*) Life Sciences, Biotechnology or Biomedicine

UKM; Münster; Hybrid; EUR 32.000 - 42.000; Teilzeit

Benefits dieser Stelle

30 Tage Urlaub

Weiterbildungsmöglichkeiten

Laborausstattung und Supervision

Jobticket

Jobrad

Cafeteria und Essensangebote

Zusammenfassung

UKM sucht einen PhD-Studenten (gn*) im Bereich Life Sciences, Biotechnologie oder Biomedizin in Münster. Die Stelle ist auf drei Jahre befristet und zu 65% Teilzeit gemäß TV-L E13 vorgesehen.

Sie arbeiten im Department of Medicine D an der Erforschung der Podocyten-Beziehungen und der Zell-contact Signale, einschließlich moderner Bildgebung und Molekularbiologie. Eine interdisziplinäre Zusammenarbeit ist vorgesehen.

Qualifikationen

• Abgeschlossenes Hochschulstudium (M.Sc.) in Life Sciences, Biotechnologie, Biochemie oder Biomedizin.
• Sehr gute Kenntnisse in molekularer und zellulärer Biologie.
• Praktische Erfahrungen mit Zellkulturen.
• Bereitschaft zur tierexperimentellen Forschung.
• Gute Kenntnis der konfokalen Mikroskopie.
• Sehr gute Englischkenntnisse.

Aufgaben

• Arbeiten mit genetisch modifizierten Mauslinien.
• Analyse von Transcriptom- und Phosphoproteomdaten aus Gewebe und Zellen.
• Anwendung hochauflösender Mikroskopie-Techniken.
• Durchführung komplexer genetischer Modifikationen von Zelllinien.
• Molekular- und zellbiologische Analysen zu Podocyten.

Kenntnisse

Molekulare Biologie

Zellkultur

Konfokale Mikroskopie

Englischkenntnisse

Ausbildung

M.Sc. in Life Sciences / Biotechnologie / Biomedizin

Jobbeschreibung

PhD Student (gn*) Life Sciences, Biotechnology or Biomedicine

Job Id: 12604

Fixed-term for 3 years | Part-time at 65% | Salary according to TV-L E13 | Department of Medicine D

We are UKM. We have a clear social mission and, with our focus on healthcare, research, and teaching, we bear a unique responsibility.

To meet our high standards every day, we are looking forward to your scientific expertise in the Department of Medicine D – ideally with you on board!

Chronic kidney diseases are among the ten most common causes of death worldwide. Highly specialized podocytes play a central role in the kidney’s filtration function. Many nephrotic syndromes are caused by genetic variants in podocyte-specific proteins. One of these is Crumbs2, an apical polarity and cell-contact protein whose loss leads to damage of the kidney filtration barrier and can ultimately result in chronic kidney disease.

This project investigates the crosstalk between apical cell contacts – depending on Crumbs2 – and focal adhesions in podocytes. Genetically modified mouse models and cell lines as well as high-resolution microscopy, molecular biology methods, transcriptomic analyses, and proteomic analyses will be used to address this research question.

RESPONSIBILITIES:

• Working with genetically modified mouse lines
• Processing and analysis of transcriptomic and phosphoproteomic samples from murine tissue and cell cultures
• Application of high-resolution microscopy techniques
• Complex genetic modification of cell lines
• Molecular and cell biological analyses to investigate podocytes

REQUIREMENTS:

• Completed university degree (M.Sc.) in Life Sciences, Biotechnology, Biochemistry or Biomedicine
• Very good knowledge of molecular and cell biology
• Practical experience with cell culture
• Willingness to conduct animal-based research as part of the research project
• Good knowledge of confocal microscopy
• Very good command of English
• Independent, structured and goal-oriented approach to work as well as reliability and team orientation

WE OFFER:

• Salary according to TV-L E13, Extra annual payment, and company pension plan (VBL)
• 30 days of vacation per year, plus two additional days off on Christmas Eve and New Year's Eve
• A wide range of training and professional development opportunities
• A well-equipped laboratory and close individual supervision
• A respectful and appreciative work environment within an interdisciplinary team of biologists and physicians
• Support and advisory services for health and work-life balance
• Additional benefits such as sports programs, job ticket, jobrad, company events, cafeteria, and emergency childcare

Equal Opportunities:
Equal opportunities are an integral part of our HR policy. UKM supports the compatibility of career and family life and has been certified as a family-conscious employer since 2010. In principle, part-time employment is possible. In areas where women are underrepresented, they will be given preferential consideration in accordance with statutory provisions, provided they have equal qualifications, aptitude, and professional performance. Applicants with severe disabilities will also be given preferential consideration under the same conditions and within the framework of legal regulations.

Further Information:

• Due to the legal requirements of the German Measles Protection Act, employment with us is only possible with full vaccination protection against measles.
  
• We reserve the right to close the selection process as soon as a suitable candidate has been found.
  
• Applications submitted by email or post cannot be considered.
  
• Salary according to TV-L. Classification is based on the assigned responsibilities and qualifications. Placement within the pay scale levels is determined according to relevant professional experience.