PhD Student â Quantitative Spatial Biology Research Group

Universitätsmedizin Frankfurt; Frankfurt; Vor Ort; EUR 45.000 - 55.000; Vollzeit

Zusammenfassung

A leading research institute in Frankfurt is seeking a highly motivated PhD Student to join their Quantitative Spatial Cancer Biology group. The successful candidate will explore the interaction mechanisms of pre-malignant cells and their environment using innovative technologies. This position offers excellent mentoring, mobility benefits, and participation in qualification programs.

Leistungen

Free public transport in all Hessen

Opportunities with national and international expert laboratories

Childcare in the daycare center

Regular health promotion courses

Training and qualification programs

Work-Life-Balance options

Qualifikationen

• Experience in flow cytometry and imaging is a plus.
• Felasa accreditation or previous experience with animal models is a plus.
• Valid proof of measles immunity/measles vaccination is required.

Aufgaben

• Join the Quantitative Spatial Cancer Biology research group.
• Utilize single-cell technologies and in vivo models.
• Investigate the interactions between pre-malignant cells and local tissue microenvironments.

Kenntnisse

Experience in basic laboratory techniques

Passion for discovery

Good communication skills

Previous experience in immunofluorescence staining

Proficiency in spoken and written English

Ausbildung

Master’s degree in life sciences, biology, or equivalent

Jobbeschreibung

Overview

We are seeking a highly motivated PhD Student to join our Quantitative Spatial Cancer Biology research group at the Dr. Senckenberg Institute of Pathology and the Mildred Scheel Career Center (MSNZ) Frankfurt, an excellence program supporting careers in translational cancer research (funded by the German Cancer Aid). The lab headed by Dr. Konstantinos Kokkaliaris specializes in hematopoietic stem-cell biology and bone marrow tissue organization in health aging and cancer. We use innovative single-cell protein profiling technologies including cutting-edge multiplex 3D tissue imaging, multicolor flow cytometry and mass cytometry. The focus of the lab is to better understand tissue organization in homeostasis aging and disease as well as further develop multiplex tissue imaging modalities. We are looking for a candidate interested in deciphering the cross-talk mechanisms through which pre-malignant cells interact and prime their local tissue microenvironment to favor disease transformation at the expense of healthy tissue function using single-cell technologies and in vivo models.

The project aims to define the key cellular, molecular and structural alterations in the bone marrow in pre-malignant conditions. We will focus on targetable interactions between pre-malignant cells and their spatial tumor microenvironment(s) to bypass malignant transformation while enhancing healthy tissue function. Our goal is to leverage those findings towards designing and functional validation of novel therapeutic intervention strategies for longer disease-free survival against hematologic conditions that often lead to acute myeloid leukemia (i.e. clonal hematopoiesis).

Publications

Relevant Publications :

Hofmann J. and Kokkaliaris KD. Bone marrow niches for hematopoietic stem cells: life span dynamics and adaptation to acute stress. Blood. 2020; 144(1): 2134.

Kokkaliaris KD and Scadden DT. Cell interactions in the bone marrow microenvironment affecting myeloid malignancies. Blood Advances. 4(15): 3795-3803. (Cover story)

Kokkaliaris KD

• Kunz L Cabezas-Wallscheid N Christodoulou C Renders S Camargo F Trumpp A Scadden DT Schroeder T
• Adult blood stem cell localization reflects the abundance of reported bone marrow niche cell types and their combinations. Blood. 2020; 136(20): 2296-2307.
• co-corresponding authors (Cover story)

Coutu D, Kokkaliaris KD, Kunz L, Schroeder T. Multicolor quantitative confocal imaging cytometry. Nature Methods 2018; 15: 39-46. co-first authors

Coutu D, Kokkaliaris KD, Kunz L, Schroeder T. Three-dimensional map of nonhematopoietic bone and bone-marrow cells and molecules. Nature Biotechnology 2017; 35(12): 1202-1210. co-first authors (Cover story)

Qualifications

• Master’s degree in life sciences, biology, or equivalent
• Experience in basic laboratory techniques (i.e., molecular biology)
• Passion for discovery, collaborative spirit, and good communication skills
• Previous experience in immunofluorescence staining, flow cytometry and imaging is a plus
• Felasa accreditation or previous experience with animal models is a plus
• Proficiency in spoken and written English
• Due to legal regulations, valid proof of measles immunity / measles vaccination is required

Environment & Benefits

• Scientific Environment: Excellent scientific environment with dedicated mentoring and training on cutting-edge single-cell technologies
• Collaboration: Opportunities with national and international expert laboratories
• Mobility: Free public transport in all Hessen (Free State Ticket Hessen)
• Training: Participation in training and qualification programs of the MSNZ and the Goethe University
• Collective agreement: The position (65% - E 13) is initially limited for 3 years with the possibility for extension
• Work-Life-Balance: Part-time employment is possible; childcare in our daycare center
• Campus: University hospital campus with modern facilities and green spaces
• Health Promotion: Regular online and face-to-face courses on nutrition, relaxation, sports and exercise

Application

Contact : Dr. Konstantinos Kokkaliaris

Email :

Application Deadline : 31.08.2025

Please submit your application online including your CV, degrees / transcripts of records, short motivation statement (1 page maximum) and one reference letter.

We welcome applications from candidates of all genders. Women are currently underrepresented in these positions at Universitätsmedizin Frankfurt. Therefore applications from women are especially encouraged. Applicants with severe disabilities will be given preferential consideration in cases of equal personal and professional qualifications.

Key Skills

Logistics & Procurement, Community Support, Fire And Safety Engineering, Informatica, Data Analysis

Employment Type : Full-Time

Experience : years

Vacancy : 1