PhD/Postdoc – Computational Biology & Multi-Omics (m/f/d)

Universitätsklinikum Heidelberg; Heidelberg; Vor Ort; EUR 52.000 - 76.000; Vollzeit

Zusammenfassung

Universitätsklinikum Heidelberg invites a computational biologist to join an interdisciplinary team exploring the molecular mechanisms of human brain development through cutting-edge genomics and computational biology approaches.

You will work at the interface of bioinformatics, neurodevelopment and gene regulation, collaborating with leading experts in systems biology and genomics; the position offers opportunities for scientific publishing, international networking and academic career

Qualifikationen

• Background in bioinformatics or computational biology.
• Experience with omics data preprocessing and pipeline development.
• Experience with high-performance computing environments.
• Proficiency in R or Python and shell scripting.
• Interest in gene regulation and developmental biology.
• Ability to work independently and in a multidisciplinary team.
• Excellent written and spoken English.

Aufgaben

• Establish computational pipelines for single-cell multi-omics data to infer gene regulation in 3D forebrain organoids.
• Design and build an interactive, open-access web platform for visualization of multi-omics data.
• Integrate newly generated data with in-house and public datasets for robust interpretation.
• Ensure reproducibility and documentation of workflows in HPC environments.
• Collaborate with computational biology experts and wet-lab researchers for data interpretation.
• Maintain documentation on eLab and provide progress reports.
• Present findings at lab meetings, journals, and grant applications.

Kenntnisse

Bioinformatics

Omics pipelines

R or Python

Shell scripting

Gene regulation

Epigenomics (optional)

Independent work

English proficiency

Jobbeschreibung

Join an interdisciplinary research team investigating the molecular mechanisms of human brain development using cutting-edge genomics and computational biology approaches. Embedded within Heidelberg’s outstanding computational biology ecosystem, you will work at the interface of bioinformatics, neurodevelopment and gene regulation while collaborating closely with leading experts in systems biology and genomics. The position offers excellent opportunities for scientific publishing, international networking and academic career development.

Our group studies the fundamental principles of embryonic neuronal development by combining genomics, gene editing, and bioinformatics. We offer an international, dynamic, and supportive research environment that fosters creativity and career growth. The AG Laugsch is embedded within Heidelberg’s excellent computational biology network, fostering close collaborations with experts like Carl Herrmann (Institute of Pharmacy and Molecular Biotechnology), and Julio Saez-Rodriguez (Systems Biomedicine, Institute of Computational Biomedicine. If you are a curiosity-driven researcher who enjoys interdisciplinary teamwork and tackling complex biological questions through data, we would be delighted to hear from you. The application must include your motivation, a brief statement of your scientific interests, contact details from three references, curriculum vitae, separated publication list, and relevant certificates.

https://www.klinikum.uni-heidelberg.de/humangenetik/forschung/ag-laugsch/

Literature:

https://doi.org/10.64898/2026.06.25.734423

https://doi.org/10.64898/2026.05.01.722223

doi: 10.1016/j.stem.2019.03.004.

Ihre Aufgaben

• Establish computational pipelines for the analysis and integration of single-cell multi-omics data (scRNA-seq, scATAC-seq, Multiome) to reconstruct gene regulatory networks in 3D forebrain dorsal organoids to determine pathophysiological consequences of aberrant NR2F1 dosage
• Design and build an interactive, open-access web platform for visualization and usage of multi-omics datasets
• Integrate newly generated data with in-house and publicly available datasets to interpret results in a robust biological context
• Ensure reproducibility, data management, and documentation of computational workflows in high-performance computing environments
• Collaborate closely with experts in computational biology across the university and affiliated institutes, as well as with experimental researchers (wet lab) in the AG Laugsch, to support accurate data interpretation and integration
• Maintain clear documentation of analyses and computational workflows on eLab and provide regular progress reports and updates
• Actively participate in regular journal clubs and institute meetings. Present findings at lab meetings and international conferences and contribute to manuscripts and grant applications.

Your Profile

• Strong background in bioinformatics or computational biology
• Practical experience with omics data pre-processing, pipeline development, and high-performance computing
• Proficiency in R or Python, and shell scripting
• Interest in gene regulation and developmental biology
• Optional previous experience with epigenomic data analysis or gene regulatory network inference
• Ability to work independently and collaboratively in a multidisciplinary environment
• Excellent written and spoken English skills

Über uns

For further information please contact Dr. rer. nat. Magdalena Laugsch via e-mail.

Advance neurodevelopment research!

till 31.08.2026 online.