PhD position in Bacterial Cell Biology (doctoral research assistant)

Philipps-Universität Marburg; Marburg; On-site; EUR 43,000 - 62,000; Full time

Benefits offered by this job

Public transport ticket

Home office option

VBL pension

Job summary

Philipps-Universität Marburg invites applications for a PhD position within the Research Training Group Microbial Nucleotide Metabolism (GRK 2937). The project investigates the ParAB_S partitioning system using cell biology, genetics, biochemistry, biophysics, and computation to understand bacterial DNA segregation.

The position is limited to three years with a starting date as soon as possible. Salary and benefits follow the public service framework in Hesse (TV-H E 13, 65%).

Qualifications

• MSc in molecular microbiology or biochemistry.
• Hands-on experience with standard molecular biology techniques and bacterial genetic manipulation.
• Experience in purification and biochemical characterization of proteins.
• Proficiency in using standard biology software and resources.
• Advantageous: ChIP-seq analysis, fluorescence microscopy, and/or bioinformatics.
• Excellent English communication and ability to work in international teams.

Responsibilities

• Scientific services in research.
• Analyze protein localization dynamics with live-cell fluorescence.
• Biochemical, biophysical and structural characterization of purified proteins.
• System-wide interaction analyses via proteomics and ChIP-seq workflows.
• Collaborate in an international, multidisciplinary environment.
• Disseminate research results at conferences and in publications.

Skills

M.Sc. in molecular microbiology

Molecular biology

Genetic manipulation

Protein purification

Biochemical characterization

Bioinformatics tools

Fluorescence microscopy

ChIP-seq experience

English proficiency

Education

Master's degree in molecular microbiology or biochemistry

Tools

Biology software

Structural biology databases

Job description

in the context of the Research Training Group Microbial Nucleotide Metabolism (GRK 2937), funded by the German Research Foundation (DFG). The position is limited to a duration of 3 years. The starting date is as soon as possible. Salary and benefits commensurate with a public service position in the state Hesse, Germany (TV-H E 13, 65%).

Nucleotides play a critical role in bacterial physiology, driving fundamental processes such as DNA/RNA biosynthesis, cell envelope biogenesis, and energy metabolism. The Research Training Group \"Microbial Nucleotide Metabolism\" (GRK 2937) aims to elucidate the molecular mechanisms mediating vital nucleotide-dependent processes. Furthermore, it provides doctoral candidates with a comprehensive, structured training program designed to equip them with a broad knowledge base and an advanced molecular microbiology skillset. Within this framework, the open PhD position focuses on the mechanisms driving bacterial DNA segregation. In particular, the successful candidate will investigate the mechanistic principles underlying the function and organization of the conserved ParAB_S_ partitioning system, using a combination of cell biological, genetic, biochemical, biophysical and computational approaches. These studies will shed light on fundamental principles of cellular organization in bacteria while preparing the candidate for a successful career in the life sciences.

Tasks

• Scientific services in research
• Analysis of protein localization dynamics using advanced live-cell fluorescence techniques
• Biochemical, biophysical and structural biological characterization of purified proteins
• System-wide interaction analyses using current proteomics & ChIP-seq workflows
• Cooperative research in a diverse, international, and multidisciplinary environment
• Communication and dissemination of research results publications and presentations at (inter)national conferences

Disposition to own scientific qualification is expected.

Profile

• M.Sc. degree (or equivalent) in molecular microbiology or biochemistry
• Comprehensive hands-on experience with standard molecular biology techniques and with the genetic manipulatation of bacteria
• Experience in the purification and biochemical characterization of proteins
• Proficiency in using standard biological and structural biology software, databases, and online resources
• Advantageous: prior experience in ChIP-seq analysis, fluorescence microscopy, and/or bioinformatics
• Excellent communication skills in English & ability to work both independently and collaboratively within an international, interdisciplinary research environment

We offer

• A dynamic international research environment in one of the centers of microbiological research in Europe
• A comprehensive and state-of-the-art technical and facility infrastructure
• Support for international researchers from the International Office of the Philipps-Universität Marburg
• Ticket for free use of public transport in the state Hesse, Germany (Landesticket)
• Possibility of home office
• Company extra pension scheme (VBL)

We actively support the professional development of junior researchers by the offers of Marburg Research Academy (MARA) and the International Office.

Contact for more Information

Prof. Dr. Martin Thanbichler

[phone]

[e-mail]

We support women and strongly encourage them to apply. In areas where women are underrepresented, female applicants will be preferred in case of equal qualifications. As a certified family-friendly university, we support our employees in balancing family and career. A reduction of working time is possible. Applicants with a disability as discribed in the Social Security Code (Section 2(2) and (3) of Book IX of the Social Security Code (SGB IX)) will be preferred in case of equal qualifications. Application and interview costs can not be refunded.