Associate Principal Scientist - Biochemical Assay Development (all genders)

Bayer; Wülfrath; Vor Ort; EUR 70.000 - 90.000; Vollzeit

Zusammenfassung

A leading global life sciences company in Wülfrath seeks an Associate Principal Scientist for Biochemical Assay Development. This role focuses on innovative drug discovery projects, requiring a PhD in Biochemistry and expertise in biochemical assay development. You will analyze scientific questions and develop assays while collaborating with various experts. The position offers a competitive compensation package and flexible working models.

Leistungen

Competitive salary and bonus

Flexible work arrangements

Family support programs

Professional development opportunities

Health and well-being initiatives

Inclusive work environment

Qualifikationen

• Post-graduate training in an industrial or academic environment.
• Initial work experience in biochemical assay development.
• Deep knowledge of enzymology and protein interaction assays.

Aufgaben

• Develop and implement assay systems for drug discovery.
• Analyze key scientific questions and contribute to strategy.
• Collaborate with interdisciplinary teams.

Kenntnisse

Biochemical assay development

Protein biology

Enzyme kinetics

Fluorescence Polarisation

Strong communication skills

Ausbildung

PhD in Biochemistry or equivalent

Tools

TR-FRET

Protein expression systems

Structural biology methods

Jobbeschreibung

At Bayer we’re visionaries, driven to solve the world’s toughest challenges and striving for a world where ,Health for all, Hunger for none’ is no longer a dream, but a real possibility. We’re doing it with energy, curiosity and sheer dedication, always learning from unique perspectives of those around us, expanding our thinking, growing our capabilities and redefining ‘impossible’. There are so many reasons to join us. If you’re hungry to build a varied and meaningful career in a community of brilliant and diverse minds to make a real difference, there’s only one choice.

Associate Principal Scientist - Biochemical Assay Development (all genders)

As an Associate Principal Scientist - Biochemical Assay Development (all genders) , you will work on innovative drug discovery projects and be an active member of highly interdisciplinary and cross-organizational research teams. With your expertise in biochemistry and cell biology, you will develop and implement tailored assay systems for data-driven decision-making. You will analyze key scientific questions in projects, create strategies and assays to link targets and modalities, and contribute to solving complex biological questions. Thanks to your experience and strategic thinking, you will make a crucial contribution to advancing research – driving medical progress and serving patients.

YOUR TASKS AND RESPONSIBILITIES

Your focus is on drug discovery projects and being an active member of highly interdisciplinary and cross-organizational teams

Using your expertise in protein biology, you develop strategies to understand the links between targets and modalities, identify tailored lead finding approaches and develop relevant assay systems to probe target biology

You develop biochemical assays for enzymes, protein-protein interaction and protein degradation

You establish novel enzymatic readout cascades, analysis of enzyme kinetics and study of biophysical drug / protein interaction

Identifing druggable entry points and relevant MoAs and establishing biochemical assays in high throughput formats (e.g. TR-FRET, FP) fall under your tasks

Performing High Throughput Screens with robotic systems is part of your responsibility

You critically assess key scientific questions in projects and develop and execute fit-to-purpose biological assays for data driven decision making

You seamlessly collaborate with disease biologists, modality experts, drug discovery scientists and computational biologists to develop state-of-the-art methods and techniques to answer complex biological questions

You keep up to date with the latest advances in assay development and drug discovery technologies by scouting innovation opportunities with external partners

You engage with the broader scientific community through publications and conference presentations

Supervising and mentoring lab associates, interns and postdocs to drive scientific projects are part of your function

WHO YOU ARE

You have completed a PhD degree in Biochemistry or equivalent with post-graduate training in an industrial or academic environment

You bring initial work experience and expertise in biochemical assay development (e.g. TR-FRET, Flourescence Polarisation), and its application to complex biological problems in drug discovery

You demonstrate a deep knowledge of enzymology, enzyme kinetics, protein / protein interaction assays

Your experience in protein expression and production in eukaryotic, insect and bacterial cells contributes to your profile

You have expert understanding of, and have worked with, a variety of biophysical methods like SPR, TSA, MS or MST

Your knowledge of structural biology (X-Ray, cryoEM, alphafold, molecular modelling, etc.) is a plus

You have hands-on experience with protein biology, structural biology, molecular biology and lab automation

You exhibit broad knowledge of modalities available to address different targets

You are digitally literate, with the ability to use digital analysis tools to effortlessly communicate with computational biologists and data scientists

You are a strategic thinker with a strong interest for drug discovery, driven by the purpose of helping patients in need

Your fluent English with excellent verbal, written communication and interpersonal skills to work across functions and within external collaborations rounds off your profile

ADDITIONAL INFORMATION

This is a fixed-term contract for 24 months.

WHAT WE OFFER

Our benefits package is flexible, appreciative, and tailored to your lifestyle, because : What matters to you, matters to us!

• We ensure your financial stability through a competitive compensation package, consisting of an attractive base pay and our annual bonus. In addition, managers can recognize special contributions by granting an individual performance award.
• Whether it’s hybrid work models or part-time arrangements : Whenever it is possible, you will have the flexibility to work how, when and where it is best for you.
• Your family is a top priority. We offer loving company daycare centers at multiple locations, support in finding childcare, time off for the care of elderly or dependent family members, summer camps for children, and much more.
• We support your professional growth by providing access to learning and development opportunities, training programs through the Bayer Learning Academy, development dialogues, as well as coaching and mentoring programs.
• We support your health and well-being with free check-ups by our company doctor, health seminars, and a wide range of initiatives that promote a healthy lifestyle.
• We embrace diversity by providing an inclusive work environment in which you are welcomed, supported, and encouraged to bring your whole self to work.

Be You. Be Bayer.

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